Engitix · London
Scientist, Macrophage & Myeloid Biology
YOUR MISSION Engitix Therapeutics is a pioneering biotechnology company unlocking extracellular matrix (ECM) biology to develop transformative therapeutics for...
YOUR MISSION
Engitix Therapeutics is a pioneering biotechnology company unlocking extracellular matrix (ECM) biology to develop transformative
therapeutics for fibrosis and oncology. By combining proprietary human ECM-based platforms with advanced cellular models, we are
uncovering novel biology at the immune-stromal interface and translating these insights into innovative drug discovery
programmes.
We are seeking a talented Scientist with expertise in macrophage and myeloid biology to join our Discovery Biology team.
The Role
This is an exciting opportunity to play a key role in advancing our understanding of macrophage and myeloid cell biology in
fibrosis and cancer.
You will combine expertise in primary human immune cells with cutting-edge cellular and functional assays to investigate
macrophage heterogeneity, activation states, and immune-stromal interactions within disease-relevant microenvironments. Working
closely with colleagues across Discovery Biology, BioPlatforms and Data Science, you will generate insights that support target
discovery, mechanism-of-action studies, and therapeutic screening efforts.
The successful candidate will be a highly motivated experimental scientist who enjoys working at the bench and is excited by the
opportunity to establish new biological capabilities, develop innovative cellular models and assays, and contribute directly to
discovery programmes. This role offers significant scientific ownership, exposure to early drug discovery, and the opportunity to
apply state-of-the-art immunology approaches to uncover novel biology and therapeutic opportunities.
Key Responsibilities
- Establish scalable workflows for processing human blood and leukopak samples, including PBMC isolation and generation of
primary human macrophages.
- Develop, optimise, and execute functional assays using primary and engineered immune cells, with a particular focus on
macrophages and other myeloid cell populations.
- Perform multi-colour and high-parameter flow cytometry for immune cell phenotyping and functional characterisation.
- Design and execute macrophage activation, phagocytosis, cytokine secretion, and co-culture assays to investigate target biology
and therapeutic activity.
- Develop and apply approaches to understand macrophage heterogeneity and function within disease-relevant microenvironments.
- Support the development of immune-stromal and ECM-based cellular models for target discovery and therapeutic screening.
- Analyse, interpret, and communicate experimental findings to multidisciplinary project teams.
- Contribute to the development of new macrophage and myeloid biology capabilities through implementation of innovative
technologies, cellular models, and experimental approaches.
- Maintain accurate laboratory records and support safe and efficient laboratory operations.
YOUR PROFILE
Essential
- Strong background in macrophage and myeloid cell biology.
- Significant hands-on experience handling human blood samples, leukopak processing, PBMC isolation, and immune cell culture.
- Experience deriving, characterising, and functionally evaluating primary human macrophages.
- Strong experience with multi-colour and/or high-parameter flow cytometry, including immune phenotyping and data analysis.
- Experience developing and executing immune cell-based functional assays.
- Strong experimental, analytical, and problem-solving skills.
- Excellent communication skills and ability to work effectively within multidisciplinary teams.
Desirable
- Experience in immuno-oncology, fibrosis, inflammation, or tissue remodelling research.
- Experience with antibody-based therapeutics or immune-modulating agents.
- Experience with stromal biology, extracellular matrix biology, or immune-stromal co-culture systems.
- Experience with molecular biology techniques such as qPCR, RNA analysis, CRISPR-based perturbation, or gene knockdown
approaches.
- Previous experience in a biotechnology or pharmaceutical research environment.
Qualifications
- PhD in Immunology, Cell Biology, Biomedical Sciences, Cancer Biology, or a related discipline.
- Typically 2–4 years of relevant postdoctoral and/or industry experience.
- Demonstrated ability to independently design, execute, troubleshoot, and interpret experiments.
- Passion for hands-on laboratory research and scientific discovery.
WHY US?
- Work at the forefront of immune-stromal biology in fibrosis and oncology.
- Contribute directly to target discovery and early drug development programmes.
- Apply cutting-edge technologies to answer important biological questions with therapeutic relevance.
- Collaborate within a highly multidisciplinary internal and external teams and innovative research environment.
- Gain broad exposure to drug discovery while maintaining strong scientific and technical ownership.
- Help deliver transformative therapies for patients with significant unmet medical need.
Roll
Scientist, Macrophage & Myeloid Biology
Kategori
Discovery Sciences
Plats
Publicerad
17 juli
Sista ansökningsdag
16 augusti