Researcher in CRISPR gene therapy group

Researcher in Cell Therapy Process Development 

Centre for Advanced Cell Therapy (ACT), Oslo University Hospital 

A 2-year position as a researcher is available at the Centre for Advanced Cell Therapy (ACT), Oslo University Hospital, under the supervision of the ACT Director Anna Pasetto. The position will be located at the pre-GMP facility at the Norwegian Radium Hospital, Oslo. The ACT Centre is a core facility and translational research environment dedicated to accelerating the development and clinical implementation of advanced cell therapies. We are looking for a highly motivated candidate with a strong interest in translational cell therapy, process development, and quality control methods for advanced therapy medicinal products. ​About the project​ The successful candidate will work on the optimization and development of manufacturing and quality control processes for cell therapy products. The project will involve the development, testing, and implementation of new protocols for cell therapy manufacturing, analytical characterization, and potency/functionality assessment. A key focus will be the introduction and evaluation of automated solutions for manufacturing and QC workflows, in close collaboration with national and international academic and industry partners. The work will be performed in the pre-GMP facility at the Norwegian Radium Hospital and will support the translation of innovative cell therapy approaches towards clinical application.   Oslo University Hospital is a workplace with great diversity. We believe this is crucial to solving our tasks in the best possible way. We want this diversity to be reflected among the applicants for our positions, and encourage all qualified candidates, regardless of background, to apply. Main tasks​ • ​Develop and optimize manufacturing protocols for cell therapy products, including T cells, NK cells, iPSC-derived products, or related cell platforms. • Establish and validate analytical methods for cell therapy process development. • Perform advanced cell culture, expansion, activation, differentiation and genetic modification workflows, depending on the project needs. • Design and perform functionality assays relevant to cell therapy products. • Use multiparameter flow cytometry for phenotypic and functional characterization. • Apply molecular biology methods; experience with ddPCR is considered an advantage. • Contribute to the evaluation and implementation of automated systems for manufacturing and QC. • Collaborate with industry partners and multidisciplinary teams within ACT and Oslo University Hospital. • Contribute to documentation, reporting, publication of results, and preparation of protocols relevant for translational and clinical development. Qualifications​ The applicant must hold a PhD in immunology, cell biology, biotechnology, molecular biology, biomedical sciences, or a related discipline. The ideal candidate has: • Hands-on experience with translational cell therapy research and/or process development. • Practical experience with cell therapy platforms such as T cells, NK cells, iPSC-derived cells, or similar advanced cellular products. • Strong expertise in mammalian cell culture and cell-based functional assays. • Documented experience with flow cytometry, including assay design, acquisition, and data analysis. • Experience with basic molecular biology techniques. • Experience with ddPCR, cell therapy manufacturing workflows, automated platforms, or GMP/pre-GMP environments will be considered an advantage. • Good understanding of the requirements for translation of cell therapy products towards clinical use. • Excellent communication and teamwork skills. • Ability to work independently, systematically, and in a multidisciplinary environment. • Good written and oral English skills. Personal qualities​ We are looking for a candidate who is scientifically curious, technically skilled, solution-oriented, and motivated to contribute to the clinical translation of advanced cell therapies. The candidate should enjoy working in a collaborative environment and be comfortable interacting with academic researchers, clinical teams, technical staff, and industry partners. We offer​ • A 2-year full-time researcher position in a highly translational and international cell therapy environment. • The opportunity to work at the interface between research, process development, manufacturing, QC, and clinical translation. • Access to state-of-the-art infrastructure at the ACT Centre and the pre-GMP facility at Radiumhospitalet. • Collaboration with leading academic and industry partners in the field of advanced cell therapy. • A stimulating, multidisciplinary workplace at Oslo University Hospital. The position is based at the Norwegian Radium Hospital, Oslo University Hospital.  ​ Kontaktinformasjon​Anna Pasetto, Unit leader, annpas@ous-hf.no; anna.pasetto@medisin.uio.no Arbeidssted​Ullernchausseen 70 0310 Oslo Nøkkelinformasjon:​Arbeidsgiver: Oslo universitetssykehus HF Referansenr.: 5150532921 Stillingsprosent: 100% Contract Søknadsfrist: 24.07.2026

PhD-stipendiatstilling innen glykomikk og sepsis

OsloMet - storbyuniversitetet

Om stillingen​ Ved Fakultet for helsevitenskap, Institutt for naturvitenskapelige helsefag, er det en ledig stilling som ph.d.-stipendiat for å undersøke anvendelse av glykomikk til å diagnostisere sepsis. Stillingen har en varighet på tre år, med ønsket oppstart senest 01.04.27. Prosjektet er et tverrfaglig forskningssamarbeid mellom glykomikkgruppen ledet av professor Niclas Karlsson og SEPSOMICS-gruppen ved Oslo Universitetssykehus, Ullevål. Målet er å identifisere undergrupper av sepsispasienter basert på deres glykoproteiner, for å forbedre diagnostikk og muliggjøre persontilpasset behandling. Prosjektet vil benytte topp moderne MS- og ikke-MS-baserte glykomikkmetoder sammenstilt med klinisk pasientinformasjon. Forskningsområde​ Dette ph.d.-prosjektet vil utforske sepsisens glykobiologi, med mål om å identifisere glykanbaserte biomarkører for pasientstratifisering og bedre behandling. Sepsis er en alvorlig tilstand forårsaket av en dysregulert immunrespons på infeksjon, med en dødelighet på mellom 15 % og 30 %. Det er et akutt behov for å forstå de molekylære mekanismene bak denne dysreguleringen for å muliggjøre persontilpasset behandling.   Vi vil studere endret plasmaglykosylering hos sepsispasienter, samt glykosyleringsmønstre i ekstracellulære vesikler (EV) som frigjøres under sepsis og kan gi ny innsikt i immundysreguleringen som kjennetegner pasientene. Målet er å identifisere en glykofenotype hos pasienter med sepsis som muliggjøre målrettet behandling og reduserer unødvendig bruk av bredspektrede antibiotika. Prosjektet støttes av et verdensledende team innen glykomikk og EV-biokjemi, og vil utnytte en høykvalitets biobank med norske sepsispasienter og relevante kontrollgrupper. Som stipendiat ved OsloMet har du mulighet til å søke om stipend for lengre forskningsopphold i utlandet. Kvalifikasjonskrav og vilkår​ • Mastergrad (120 studiepoeng/ECTS) innen naturvitenskap (farmasi, analytisk kjemi, biokjemi, biomedisin eller tilsvarende) • Dokumentert erfaring med relevant biokjemisk laboratoriearbeid • Gode engelskkunnskaper, både skriftlig og muntlig • Opptak til doktorgradsprogrammet i helsevitenskap er en forutsetning for å tiltre i stillingen. For å få opptak på ph.d. -programmene på Fakultetet for helsevitenskap må søkere ha B eller bedre på masteroppgaven/hovedfagsoppgaven (eller karakter ansett som likeverdig) og gjennomsnittskarakter tilsvarende B eller bedre på mastergraden. I særskilte tilfeller kan søkere med karakteren C vurderes. I slike tilfeller vil særlig relevant erfaring knyttet til forskningsprosjekt og/eller vitenskapelig publisering bli vektlagt. Se informasjon om kriterier på nettsiden for opptak • Endelig plan for forskerutdanning skal være godkjent og avtalefestet senest 3 måneder etter tiltredelse Generelle kriterier for ansettelse som stipendiat fremgår av forskriften (Forskrift til universitets- og h.øyskoleloven- Lovdata​) Det vil være en fordel om du har​ • dokumentert erfaring med praktisk biologisk massespektrometri, glykomikk og/eller glykobiologi • erfaring fra arbeid med omics, big data og statistikk ved bruk av R eller liknende • god forståelse for biologiske sykdomsprosesser • erfaring med å bruke KI/maskinlæring for å forutsi helseutfall • ferdigheter (både skriftlig og muntlig) i et skandinavisk språk Vi tilbyr​ • en spennende utdanningsstilling ved Norges tredje største universitet • tilgang til faglig videreutvikling i et kreativt fag- og forskningsmiljø • fleksibel arbeidstid og arbeidsplass midt i Oslo sentrum • Internasjonal forskningsmobilitet, siden den valgte kandidaten forventes å være involvert i arbeidsutveksling med europeiske forskningspartnere og presentere arbeid på nasjonale og internasjonale konferanser og workshops. • Du vil ta del i et spennende og viktig forskningsprosjekt. Du vil jobbe med klinikere, biokjemiker, biostatistikere og glykobiologer for å utforske basale biologiske mekanismer i en livstruende akutt sykdomstilstand som ramme mange pasienter. • Pensjonsbetingelser i Statens pensjonskasse (SPK) • Gode velferdsordninger Stillingen lønnes iht. Hovedtariffavtalene i staten og OsloMets lønnspolitikk i stillingskode 1017 som stipendiat, ltr. 54 kr. 532 200,- pr. år. Video: https://www.youtube.com/watch?v=SHi5avzdHIkSøknadsprosess​ Vil du søke på stillingen må du søke via vårt rekrutteringssystem. Innen søknadsfristen må du laste opp følgende dokumenter:  • søknadsbrev • CV, attester og alle sider av vitnemål. Utenlandsk utdanning bør være godkjent på forhånd, og godkjenningsbrev vedlegges. Informasjon finnes via lenken: Godkjenning av utenlandsk utdanning – jobb i Norge | HK-dir • masteroppgave/hovedfasoppgave • last opp eventuelle vitenskapelige arbeider eller lenke til full artikkel • liste over eventuelle publikasjoner og presentasjoner på internasjonale semnarer/konferanse • gjerne kontaktinformasjon til to referanser  Vi behandler kun søknader sendt via vårt elektroniske rekrutteringssystem og alle dokumenter må lastes opp for at din søknad skal behandles. Dokumentene må være på et skandinavisk språk eller engelsk. Oversettelser må være autorisert og du må påregne å fremvise originaler ved et eventuelt intervju. OsloMet gjennomfører kontroll av dokumenter, slik at du som kandidat skal få en reell evaluering og rettferdig konkurranse. Ufullstendige søknader vil ikke bli tatt til vurdering. For aktuelle stillinger gjennomfører OsloMet bakgrunnssjekk av søkere i samarbeid med en ekstern leverandør, for å verifisere opplysninger som fremgår av tilgjengelige dokumenter. Bakgrunnssjekk skjer alltid med kandidatens samtykke, og ansettelse i disse stillingene forutsetter godkjent bakgrunnssjekk. Aktuelle søkere vil motta nærmere informasjon om dette. For nærmere informasjon om stillingen, kontakt: • Professor Niclas Karlsson , niclaska@oslomet.no • For administrative spørsmål HR rådgiver Kate Olsen, kateol@oslomet.no   Søknadsfrist:13.august 2026 Informasjon til deg som søker​ Inkludering og mangfold styrker vår evne til å løse OsloMets samfunnsoppdrag. Derfor ønsker vi medarbeidere med ulike kompetanser, livserfaringer og perspektiver velkommen. Vi arbeider kontinuerlig for å være en inkluderende arbeidsplass, og gjennom dialog tilrettelegger vi for medarbeidere som har behov for det.  OsloMet er EU sertifisert HR Center of Excellence for Charter & Code for forskere som støtter karrieremuligheter, mobilitet og arbeidstaker rettigheter for forskere. OsloMet har sluttet seg til prinsippene og forpliktet institusjonen til å følge anbefalingene i DORA-erklæringen (sfdora.org) (The San Francisco Declaration on Research Assessment). Ansettelsen blir gjennomført etter prinsippene i statsansatteloven og lovverk som regulerer eksport av kunnskap, teknologi og tjenester. Søkere som er i konflikt med dette regelverket vil ikke anses kvalifisert for stillingen. Besøk OsloMet på LinkedIn, Facebook, Instagram

Researcher in synthetic biology and biosynthetic gene cluster expression

NTNU - Norwegian University of Science and Technology

This is NTNU​ NTNU is a broad-based university with a technical-scientific profile and a focus in professional education. The university is located in three cities with headquarters in Trondheim. At NTNU, 9,000 employees and 43,000 students work to create knowledge for a better world. You can find more information about working at NTNU and the application process here.     Video: https://youtu.be/Xt-yHCN5QS0About the Job​ We have a vacancy for a full-time three year researcher at the Department of Biotechnology and Food Science, NTNU. The position is linked to AIMARIA – Accelerating Innovation in Marine AI-Powered Bioprospecting, a Horizon Europe Innovation Action coordinated by NTNU.  AIMARIA combines omics, bioinformatics, artificial intelligence, synthetic biology, bioprocess development and sustainability assessment to accelerate the discovery and sustainable production of marine and aquatic natural products. At NTNU, a central part of the project is the development of more predictable and efficient methods for the refactoring and heterologous expression of biosynthetic gene clusters (BGCs).  The researcher will have a leading role in developing NTNUs experimental platform for BGC expression. The work will combine molecular biology, microbial strain engineering and synthetic biology with AI-supported design of regulatory DNA elements and expression constructs. The researcher will work closely with a PhD candidate recruited to the same scientific activity and with national and international partners in the AIMARIA consortium.  The position is well suited for a researcher who would like to develop and apply advanced synthetic-biology methods to challenging microbial expression systems and contribute to the production of biologically active natural products and enzymes.  Your immediate leader is Head of the department. Duties of the position​ • Develop and implement strategies for the design, refactoring and heterologous expression of biosynthetic gene clusters.  • Design and construct expression systems, including promoters, 5′ untranslated regions and other regulatory DNA elements.  • Engineer and evaluate microbial host strains for the expression of complex biosynthetic pathways.  • Analyse and interpret molecular, expression and production data.  • Coordinate relevant NTNU activities with partners in the AIMARIA consortium.  • Contribute to project deliverables, scientific reports, presentations and peer-reviewed publications.  • Present project results at consortium meetings, scientific conferences and relevant stakeholder events.  The distribution of duties may be adjusted according to the candidate’s qualifications and the scientific development of the project.  Required selection criteria​ • A completed PhD in synthetic biology, molecular biology, biotechnology, microbiology, biochemistry, biochemical engineering or another relevant discipline.  • Documented hands-on experience in BGC refactoring, molecular cloning, DNA assembly and genetic engineering of microorganisms.  • Experience with heterologous gene expression, metabolic engineering, pathway engineering or related microbial biotechnology.  • Ability to plan, conduct, document and analyse experimental research independently.  • Experience with the analysis and interpretation of biological data.  • A scientific publication record relevant to the position.  • Excellent written and oral English language skills.  The PhD degree must have been completed and documented by the application deadline.  Preferred selection criteria​ • Experience with biosynthetic gene clusters or microbial natural-product pathways.  • Experience with Streptomyces, actinomycetes or other microbial hosts used for heterologous BGC expression.  • Experience with assembly, manipulation or expression of large DNA constructs.  • Experience with promoter engineering, regulatory-sequence design or optimisation of microbial gene expression.  • Experience with CRISPR-based genome engineering or other advanced strain-engineering methods.  • Knowledge of bioinformatics, DNA-sequence analysis or computational design tools.  • Experience with high-throughput experimental workflows, automation or design–build–test–learn cycles.  • Experience with microbial cultivation, fermentation or bioprocess development.  • Experience with metabolite analysis or interpretation of LC–MS or related analytical data.  • Experience with supervision of students or junior researchers.  • Experience from international or externally funded collaborative research projects.  • Knowledge of research-data management, open science and FAIR data principles.  Personal characteristics​ • Scientifically curious and motivated to solve complex experimental problems.  • Able to work independently while contributing actively to a collaborative research environment.  • Structured, systematic and attentive to experimental documentation and data quality.  • Proactive and able to move work forward across several parallel activities.  • Able to communicate clearly with researchers from different scientific and professional backgrounds.  • Supportive and constructive in the supervision of students and junior colleagues.  • Flexible and comfortable working in a large international consortium.  In the evaluation of which candidate is best qualified, emphasis will be placed on education, experience and personal suitability, as well as motivation, in terms of the qualification requirements specified in the advertisement.  We offer​ • Exciting and stimulating tasks in a strong international academic environment  • An open and inclusive work environment with dedicated colleagues  • Experience with coordination of a large EU-funded biotechnology and bioeconomy project.  • Favourable terms in the Norwegian Public Service Pension Fund • employee benefits Salary and conditions​ As a researcher (code 1109) you are normally renumerated depending on qualifications and seniority. As required by law, 2% of this salary will be deducted and paid into the Norwegian Public Service Pension Fund. The position is for a period of three years. The Researcher is expected to start during the autumn semester of 2026, although the precise start date can be agreed upon.  The engagement is to be made in accordance with the regulations in force concerning State Employees and Civil Servants, and the acts relating to Control of the Export of Strategic Goods, Services and Technology. Candidates who by assessment of the application and attachment are seen to conflict with the criteria in the latter law will be prohibited from recruitment to NTNU.    After the appointment you must assume that there may be changes in the area of work.  For the necessary professional and social interaction, it is a prerequisite that you are physically present and available to the institution on a daily basis.  About the application​ Your application and supporting documentation must be in English or a Scandinavian language. Please note:​ the application will only be assessed on the basis of the information we have received by the application deadline. Therefore, make sure that your application clearly shows how your skills and experience meet the criteria described above. The application and all attachments must be sent electronically via Jobbnorge.no. Applications submitted by other means will not be considerered. Please do not send separate application documents or additional information by e-mail.  If you are invited to an interview, you must bring certified copies of certificates and diplomas upon request. Your application must include: • CV, certificates and diplomas.  • A short application letter describing your motivation and relevant experience.  • A complete list of publications and other relevant scientific outputs.  • Copies of up to five scientific works that you consider particularly relevant to the position.  • A brief description of your contribution to the submitted scientific works.  • Names and contact information for three relevant referees.  • Documentation of the scope and quality of any education taken abroad. If you already have a statement from NOKUT/HK-dir, please attach this as well.  It is important that you both document and reflect on your competence. You are encouraged to use the NTNUs competence matrix as a guide for  documentation of your competence. Joint work will also be considered. If it is difficult to identify your specific input to a joint project, you must include evidence of your contributions.  In the evaluation of which candidate is best qualified, emphasis will be placed on education, experience and personal and interpersonal qualities. Motivation, ambitions, and potential will also count in the assessment of the candidates. Open scientific practice will be recognized. NTNU is obliged by the evaluation criteria for research quality in accordance with The San Fransisco Declaration on Research Assessment – DORA and The obligations in the Coalition for Advancing Research Assessment ( CoARA) on responsible assessment of research and recognition of a wider range of academic contributions to science and society. This means that we will pay particular attention to the quality and academic range demonstrated by your scientific work to date. We will also pay attention to research leadership and participation in research projects. Your scientific work from the last five years will be given the most weight. Your application will be considered by a committee at the department. Candidates of interest will be invited to an interview. General information​ NTNU believes that inclusion and diversity is a strength. We want our faculty and staff to reflect Norway’s culturally diverse population and we continuously seek to hire the best minds. This enables NTNU to increase productivity and innovation, improve decision making processes, raise employee satisfaction, compete academically with global top-ranking institutions and carry out our social responsibilities within education and research. NTNU emphasizes accessibility and encourages qualified candidates to apply regardless of gender identity, ability status, periods of unemployment or ethnic and cultural background.  As an employee at NTNU, you must at all times adhere to the changes that the development in the subject entails and the organizational changes that are adopted.   A public list of applicants with name, age, job title and municipality of residence is prepared after the application deadline. If you want to reserve yourself from entry on the public applicant list, this must be justified. Assessment will be made in accordance with current legislation. You will be notified if the reservation is not accepted.  If you have any questions about the position, please contact Rahmi Lale, e-mail: rahmi.lale@ntnu.no. If you have any questions about the recruitment process, please contact Cecilie Skagfjord, e-mail: cecilie.skagfjord@ntnu.no.  If you think this looks interesting and in line with your qualifications, please submit your application electronically via jobbnorge.no with your CV, diplomas and certificates attached. Applications submitted elsewhere will not be considered. Upon request, you must be able to obtain certified copies of your documentation.     Application deadline: 09.08.2026​ The city of Trondheim is a modern European city with a rich cultural scene. Trondheim is the innovation capital of Norway with a population of 200,000. The Norwegian welfare state, including healthcare, schools, kindergartens and overall equality, is probably the best of its kind in the world. Professional subsidized day-care for children is easily available. Furthermore, Trondheim offers great opportunities for education (including international schools) and possibilities to enjoy nature, culture and family life and has low crime rates and clean air quality.