Department of Neurology, Oslo University Hospital / GliaLab, University of Oslo Researcher and/or PhD position (fulltime).
Applications are invited for one position as Researcher ("Forsker") or PhD research fellow ("Stipendiat") in the project "AI-Driven Optogenetic Closed-Loop Seizure Control"- A 2-photon-imaging project, funded by Helse Sør-Øst (Project 340682).
The project extends our group's ongoing work on the preceding Helse Sør-Øst project (2024056, 2024-2026), and builds on our recent findings on cortical spreading depolarization (CSD) as a possible "brake" on epileptic seizures (Enger & Heuser, Front Netw Physiol 2024; Heuser et al., Cereb Cortex 2018), and on our established two-photon imaging methodology for studying astrocytic and vascular dynamics (Bojarskaite et al., Nat Commun 2023). The aim is to develop and test an AI-driven, closed-loop system that detects seizure activity in real time and triggers an optogenetic intervention (CSD or direct neuronal inhibition) with the goal of a novel, targeted treatment approach for epilepsy.
The application must contain:
- Cover letter with statement of motivation, research interests, and which track (Researcher/PhD fellow) you are applying for
- CV (summarizing education, positions and academic work)
- Copies of educational certificates (academic transcripts only; PhD diploma or confirmation of imminent completion for Researcher applicants)
- Complete list of publications and academic works
- List of reference persons: 2-3 references (name, relation to candidate, e-mail and phone number)
- Deadline for application: October 15th, 2026
- Start: November 1st, 2026, later start can be possible depending on circumstances
- Position duration: 3 years (through October 31st, 2029)
- Contact: Research group leader Kjell Heuser, Department of Neurology, Oslo University Hospital HF, dr.heuser@gmail.com, or +47 92414568, and/or Associate Professor Rune Enger, GliaLab, Institute of Basic Medical Sciences, University of Oslo, rune.enger@medisin.uio.no, or +47 90534262
The project comprises:
Two-photon imaging: In vivo two-photon imaging of astrocytes and neurons in awake, head-fixed mice through chronic cranial windows, building on our established methodology for studying cortical and hippocampal network activity.
Consolidating the conditional Kir4.1 knockout hippocampal model combined with wireless EEG telemetry.
High-density electrophysiology (Neuropixels 2.0) and miniaturized two-photon imaging (Mini2P) of astrocytes and neurons through chronic hippocampal windows, to test the role of CSD in seizure termination.
Development of an AI-based seizure-detection algorithm driving automated, closed-loop optogenetic stimulation.
The successful candidate will be based at GliaLab, Letten Centre, Institute of Basic Medical Sciences, University of Oslo (https://glialab.no), working in close collaboration with the Department of Neurology, Oslo University Hospital.
Please indicate in your application which track you are applying for (Researcher or PhD fellow), or whether you wish to be considered for either, depending on your qualifications.
Oslo University Hospital is a workplace with great diversity. We believe this is essential to perform the tasks required. We pursue diversity among our job applicants and encourage everyone to apply regardless of who you are and what background you have.
Qualifications
Requirements if hired as PhD fellow (100% position):
Completed Master's degree (or equivalent) in neuroscience, medicine, biology, biomedicine, or a related field
Documented experience with in vivo rodent experimental work
Highly motivated and accurate candidate
Good problem-solving skills
Ability to work both independently and as an integrated member of a multidisciplinary team
Good communication skills and teaching abilities
Fluent oral and written communication skills in English
Requirements if hired as Researcher (minimum 50% position):
Completed PhD (or submitted thesis with imminent defense) in neuroscience, medicine, biology, biomedicine, or a related field
Documented experience with in vivo rodent microsurgeries, as well as in vivo electrophysiology and/or imaging
FELASA-equivalent certification in laboratory animal science (or willingness to obtain this) is required; documented prior hands-on animal experimental experience will be prioritized.
Track record of first-author publication(s) in the field
Ability to co-supervise PhD students/master students and contribute to project leadership
Fluent oral and written communication skills in English
The following skills will be considered beneficial but are not obligatory:
Experience with in vivo two-photon microscopy and/or high-density electrophysiology (e.g., Neuropixels)
Experience with rodent seizure/epilepsy models
Experience with optogenetics
Programming skills (Python/MATLAB), especially relevant for machine-learning/AI seizure-detection work
Knowledge of statistical methods, including regression models or machine learning
Experience with viral vector-based conditional knockout strategies (Cre-lox)
Personal qualities
Personal qualities and team-working abilities will be an important part of the assessment.
We offer
- A workplace in the heart of Oslo, with rich opportunities for culture and outdoor activities
A safe workplace with strong support from colleagues
Excellent opportunities for professional and personal development
Contribution to an important societal mission
Training programs and courses, fostering the development of specialized skills
Employment in an IA-certified company with pension scheme and insurance
Salary in accordance with collective agreements for a Researcher/PhD position
ContactsKjell Heuser, Research group leader , 92414568, dr.heuser@gmail.com
LocationSognsvannsveien 20
0372 Oslo
Key information:Employer: Oslo universitetssykehus HF
Reference number: 5175630538
Percentage of full-time: 100%
Contract
Start date: 01/11/2026
End date: 31/10/2029
Application deadline: 15/10/2026