Clinical Program Manager, Cambridge, MA

Medical Director, Clinical Development (Oncology), Cambridge, MA

Isomorphic Labs

Isomorphic Labs is applying frontier AI to help unlock deeper scientific insights, faster breakthroughs, and life-changing medicines with an ambition to solve all disease. The future is coming. A future enabled and enriched by the incredible power of machine learning. A future in which diseases are curtailed or cured starting with better and faster drug discovery.  Come and be part of an interdisciplinary team driving groundbreaking innovation and play a meaningful role in contributing towards us achieving our ambitious goals, while being a part of an inspiring and collaborative culture. The world we want tomorrow is the one we’re building today. It starts with the culture at this company. It starts with you.    ABOUT ISO Isomorphic Labs (IsoLabs) was launched in 2021 to advance human health by building on and beyond the Nobel-winning AlphaFold system. Since then, our interdisciplinary team of drug discovery experts and machine learning specialists has built powerful new predictive and generative AI models that accelerate scientific discovery at digital speed. Our name comes from the belief that there is an underlying symmetry between biology and information science. By harnessing AI’s powerful capabilities, we can use it to model complex biological phenomena to help design novel molecules, anticipate how drugs will perform and develop innovative medicines to treat and cure some of the world’s most devastating diseases. We have built a world-leading drug design engine comprising AI models that are capable of working across multiple therapeutic areas and drug modalities. We are continually innovating on model architecture and developing cutting-edge capabilities to advance rational drug design. Every day, and with each new breakthrough, we’re getting closer to the promise of digital biology, and achieving our ambitious mission to one day solve all disease with the help of AI.   CLINICAL DEVELOPMENT MEDICAL DIRECTOR (ONCOLOGY), CAMBRIDGE, MA  Isomorphic Labs (IsoLabs) is developing and applying frontier AI to help unlock deeper scientific insights, faster breakthroughs, and life-changing medicines. The company’s ambitious mission is to one day solve all disease. IsoLabs has built multiple cutting-edge AI models that power our unified drug design engine, which can tackle a broad spectrum of disease areas and modalities. This breakthrough technology will transform how we design new drug candidates and bring new potential medicines to patients. Come and be part of an interdisciplinary team driving groundbreaking innovation. You will play a meaningful role in achieving our ambitious goals, while being a part of an inspiring and collaborative culture. Together, let’s build the future of medicine at Isomorphic Labs. ABOUT ISO Isomorphic Labs was launched in 2021 to advance human health by building on and beyond the Nobel prize-winning AlphaFold system. Since then, our interdisciplinary team of drug discovery experts and machine learning specialists has built powerful new predictive and generative AI models that accelerate scientific discovery at digital speed. Our name comes from the belief that there is an underlying symmetry between biology and information science. By harnessing AI’s powerful capabilities, we can use it to model complex biological phenomena to help design novel molecules, anticipate how drug candidates will perform in the clinic and develop medicines to treat and cure some of the world’s most devastating diseases. At IsoLabs, we are committed to leveraging state-of-the-art AI to advance precision medicine paradigms and establish new benchmarks for both efficacy and safety by consistently delivering the optimal treatments to the appropriate patients at precisely the right time, which we expect to significantly enhance our overall probability of success.  Since our founding, we have grown a world-class interdisciplinary team led by founder and CEO Sir Demis Hassabis and President Max Jaderberg. We have built strategic drug discovery collaborations with partners including Eli Lilly, Novartis and Johnson & Johnson, with the Novartis collaboration expanding in February 2025 to double its original scope. Our internal drug candidate pipeline consists of multiple programs across oncology and immunology.  In March 2025, IsoLabs raised $600 million in its first external funding round, led by Thrive Capital with participation from GV and Alphabet. In May 2026, IsoLabs raised $2.1 billion in a Series B financing round. This investment will power our world-leading AI drug design engine, scale our business globally and progress our drug candidate pipeline. The round was led by Thrive Capital, and includes participation from existing backers Alphabet and GV alongside new investors MGX, Temasek, CapitalG, and the UK Sovereign AI Fund, significantly expanding our global capital base.Isomorphic Labs is scaling globally, with headquarters in London and offices in Lausanne, Switzerland and a US base in Cambridge, Massachusetts. We continue to progress our internal candidate programs towards the clinic while advancing across a broad range of modalities including small molecules, molecular glues, peptides, and antibodies.  YOUR IMPACT  We are seeking an exceptional Medical Director, Oncology to join our team in Cambridge, MA.  You will report into our Chief Medical Officer, acting as the clinical voice for our oncology pipeline. You will be responsible for translating AI-driven insights into actionable clinical development strategies, serving as the primary medical monitor, and leading cross-functional teams to advance our therapeutic assets from discovery through clinical proof-of-concept.  As a key lead for patient safety and medical monitoring, the Medical Director partners with Clinical Operations to ensure the successful planning, execution, and implementation of clinical studies. They also serve as a subject matter expert, leading process improvement efforts and providing strategic medical guidance across various assets and indications.  This role requires exceptional collaborative and communication skills, with a proven ability to engage and influence a broad spectrum of internal and external stakeholders. The successful candidate must operate with the highest ethical standards, ensuring full compliance with internal SOPs, regulatory requirements, local laws, and Good Clinical Practice (GCP) guidelines.  The ideal candidate is a physician-scientist and translational medicine expert with experience from discovery through clinical proof of concept.  What you will do  * Provide strategic medical leadership for the design, and execution of oncology clinical trials. * Collaborating closely with clinical operations to ensure clinical trials are in alignment with patient safety standards and in compliance with FDA, EMA, ICH and GCP guidelines while also ensuring that the overall scientific and medical content of all clinical programs is scientifically and clinically rigorous.    * Serve as the medical expert and monitor for clinical studies, ensuring the highest standards of patient safety, data integrity, and protocol compliance.  * Act as the primary point of medical contact for investigators, steering committees, and study teams. * Lead the clinical content for key regulatory submissions (INDs/BLAs).  * Represent Isomorphic Labs in discussions with global health authorities and in peer-to-peer interactions with Key Opinion Leaders (KOLs) and clinical investigators.  * Collaborate seamlessly with a cross-functional clinical development team to ensure development plans are both scientifically sound and clinically actionable.  QUALIFICATIONS ESSENTIAL: * Education: MD or MD, PhD (or equivalent) in Oncology required; board certification preferred  * Significant clinical development experience within the pharmaceutical or biotechnology industry, including experience in medical monitoring and leading cross-functional teams.  * A proven track record of leading complex, cross-disciplinary projects from early-stage to clinical proof-of-concept. * Deep understanding of Oncology drug development and regulatory pathways. * Demonstrated ability to thrive in fast-paced, and evolving environments. You are a natural problem solver who sees opportunity where others see uncertainty. * Exceptional ability to communicate complex clinical and strategic concepts to diverse audiences, including senior leadership, engineering teams, and external partners. * Tech-Forward Vision: A strong interest in how AI and digital tools can be applied to drug discovery, safety monitoring, and patient stratification. * Some travel required.  CULTURE AND VALUES We are guided by our shared values. It's not about finding people who think and act in the same way. These values help to guide our work and will continue to strengthen it.  Thoughtful Thoughtful at Iso is about curiosity, creativity and care. It is about good people doing good, rigorous and future-making science every single day. Brave Brave at Iso is about fearlessness, but it’s also about initiative and integrity. The scale of the challenge demands nothing less. Determined Determined at Iso is the way we pursue our goal. It’s a confidence in our hypothesis, as well as the urgency and agility needed to deliver on it. Because disease won’t wait, so neither should we. Together Together at Iso is about connection, collaboration across fields and catalytic relationships. It’s knowing that transformation is a group project, and remembering that what we’re doing will have a real impact on real people everywhere. CREATING AN EXTRAORDINARY COMPANY We believe that to be successful we need a team with a range of skills and talents. We're building an environment where collaboration is fundamental, learning is shared and every employee feels supported and able to thrive. We value unique experiences, knowledge, backgrounds, and perspectives, and harness these qualities to create extraordinary impact. We are committed to equal employment opportunities regardless of sex, race, religion or belief, ethnic or national origin, disability, age, citizenship, marital, domestic or civil partnership status, sexual orientation, gender identity, pregnancy or related condition (including breastfeeding) or any other basis protected by applicable law. If you have a disability or additional need that requires accommodation, please do not hesitate to let us know. HYBRID WORKING It’s hugely important for us to share knowledge and build strong relationships with each other, and we find it easier to do this if we spend time together in person. This is why we follow a hybrid model, and would require you to be able to come into the office 3 days a week (currently Tuesday, Wednesday, and one other day depending on which team you’re in). If you have additional needs that would prevent you from following this hybrid approach, we’d be happy to talk through these if you’re selected for an initial screening call. Please note that when you submit an application, your data will be processed in line with our privacy policy. >> Click to view other open roles at Isomorphic Labs

Senior QA Auditor - 60% - 80%

Healx

Do you want to use your strong analytical, problem-solving skills to help find treatments for rare disease patients? About Healx Healx is an AI-powered tech bio company that is redesigning drug discovery. With 10,000 rare diseases affecting 400 million people globally, 90% of which have no approved treatment, Healx is on a mission to pioneer the next generation of drug discovery to help rare disease patients in need. We combine data, artificial intelligence and deep pharmacology expertise to develop treatments more quickly and cheaply than traditional drug discovery. Diversity and inclusion sits at the heart of our mission to help people with rare diseases, and we believe that attracting and empowering a diverse team is critical to achieving this goal. We welcome applications from people from all backgrounds and walks of life. Below we have included the qualities that we feel are required for you to excel in this role; however we appreciate that people can apply transferable skills from all walks of life and experience. If you think you have what it takes, love our mission and resonate with our values but are worried you don't tick every box – we still want to hear from you and encourage you to apply! Our Values Care for Rare – Rare disease patients are at the heart of what we do  Grow as individuals – We are learners always seeking to enhance our expertise  Win as a team – We strive to remain inclusive and diverse and we celebrate successes and lessons together Innovate and deliver – Our mission requires rapid innovation and calculated risks that won’t compromise our high standards  The role Healx is looking for a part-time (60% - 80%) experienced Senior QA Auditor to join the team to lead strong analytical, problem-solving activities that ensure all clinical research (GCP) and manufacturing (GMP) related activities performed by Healx personnel and vendors are carried out in accordance with industry expectations, SOPs, and international regulations.   Healx’s Senior QA Auditor will be working closely with Healx’s Clinical team, they will ensure Healx is inspection-ready and drives continuous quality improvement across both clinical and manufacturing activities. They will ensure all clinical research activities at Healx complies with GCP standards, SOPs, and international regulations, execute Healx’s annual audit plan, and support the team with risk management planning and training. The GMP aspect of this role involves ensuring Healx’s investigational products meet strict GMP standards through Healx’s QMS management.  Key duties include working with Healx’s CMC Director to manage review batch records, auditing (internal, external, supplier), deviation/CAPA investigation, conducting root cause analysis, documentation and change control, handling out-of-spec results, product release and ensuring adherence to regulations.  You will partner closely and report to the Global Head of Clinical Development to provide the strategic oversight and tactical execution of the Quality Management System (QMS).  You’ll be closely collaborating with CMC, Regulatory Affairs, Pre-Clinical and Clinical Operations personnel to maintain compliance and drive continuous improvement in Healx’s QMS and manufacturing of Healx’s investigational products.  

Business Development Manager

Cyted Health

ABOUT US We’re Cyted, a pioneering gastrointestinal diagnostics company transforming earlier detection for oesophageal cancer and Barrett’s oesophagus. Our EndoSign test combines a swallowable capsule with advanced biomarkers and analytics to detect disease earlier, improving patient outcomes while reducing pressures on healthcare systems. What started as an idea between a health-tech entrepreneur and leading clinical scientists in Cambridge UK, has quickly grown internationally, backed by EQT Life Sciences and a $44M Series B investment. But we still work like a startup - because we are one. Things move quickly and we’re building as we go. Some days you’ll solve brand new problems and others you’ll roll your sleeves up and get things done. We’re a collaborative team, so your work matters. We have our investors trust, but you won’t disappear into layers of hierarchy, waiting months for decisions. If you've got a good idea, we want to hear it - whatever your role. We like curious, adaptable people who are always willing to learn. This isn’t a polished corporate - we’re building as we go.  If you're excited to help build something ambitious from the ground up that makes a real difference to patients' lives - we'd love to hear from you. Our four-stage process runs on a rolling basis, with each stage serving a clear purpose. Shaped by candidate feedback, we've designed it to give you honest insights into Cyted, whatever the role. 1. Initial conversation – A relaxed online conversation with Maddie from our People team to get to know you, talk through your experience and answer any questions you have about Cyted. 2. Line manager interview – An online discussion exploring the role in more detail through scenario-based and role-specific questions. 3. Team interview & assessment – Meet the wider team in person and see how we work. You'll complete a presentation or practical assessment so we can hear your ideas and see how you approach challenges at Cyted. 4. Final Interview – Marcel, our CEO, still meets every potential new joiner. It's an opportunity to discuss your ambitions and how they align with Cyted's journey and future vision. ROLE SUMMARY We're looking for a Business Development Manager who's excited by the challenge of building something new and making a genuine difference to patients.  Earlier cancer detection doesn't happen because of great technology alone. It happens because healthcare organisations trust it, understand its value and choose to make it part of everyday patient care. You'll help create and grow Cyted's commercial presence across the Southeast US, working with health systems, IDNs, academic medical centres and gastroenterology practices to bring an innovative diagnostic solution to more patients. This is a highly autonomous, field-based role where success comes from being out in the market, meeting customers, building relationships and creating opportunities. You'll partner with clinical, operational and executive stakeholders to understand their challenges and demonstrate how Cyted can improve patient access, clinical pathways and operational efficiency. From first conversations through implementation, adoption and expansion, you'll become a trusted partner while working closely with Medical Affairs, Clinical Operations, Product and Customer Success to deliver an exceptional customer experience. We're looking for someone who's curious, proactive and enjoys building out in the field rather than maintaining. Whether you've helped grow a territory, launched something new or are ready to take the next step in your career, you'll have the opportunity to make a real impact. Your ideas, initiative and insight from the field will help shape how we engage customers, strengthen adoption and continue growing Cyted across the US. WORKING PATTERN AND LOCATION The role is a full-time position with a standard 40 hour working week. The role holder will need to frequently visit other company sites and may be required to work flexibly. IN THIS ROLE YOU WILL BE ACCOUNTABLE FOR: Health System and Specialty Care Business Growth * Developing and executing strategic sales plans to expand adoption of Cyted's diagnostic solutions across priority health systems and care settings. * Engaging clinical, operational and executive stakeholders to demonstrate clinical, operational and economic value, securing reimbursement, new business and successful implementation. * Driving customer adoption, utilisation and growth by overcoming barriers, expanding programmes and increasing access through new care delivery models. Expand Market Access and Early Detection Programs * Educating stakeholders on the clinical and economic value of earlier detection and its impact on patient outcomes, healthcare costs, and quality metrics. * Working cross-functionally with Clinical, Product, Medical Affairs, and Operations teams to support implementation and ensure customer success by redesigning care pathways that improve access to screening, diagnostic testing. * Identifying and pursuing opportunities to integrate Cyted's solutions into preventive care, population health, and risk-stratification programs. Commercial Pipeline Growth * Maintaining a robust pipeline of opportunities by developing executive-level relationships with key decision-makers and influencers across healthcare organizations. * Representing the company at industry conferences, customer meetings, and regional healthcare events. * Providing market intelligence and customer feedback to support product development, commercialization, and growth strategies. * Accurately managing sales activities, forecasts, and customer interactions within CRM systems. TO THRIVE IN THIS ROLE, YOU WILL HAVE: Qualifications & Experience * Success selling into US health systems, IDNs or specialty physician practices. * Experience launching new products, territories or services in healthcare, diagnostics, medical devices or life sciences. * Track record of generating new business and managing complex enterprise sales cycles, ensuring sustained success post-implementation. * Experience within molecular diagnostics, pathology, gastroenterology, oncology or medical devices * Understanding of healthcare reimbursement, value-based care or commercialisation of innovative diagnostics. Skills & Knowledge * Strong relationship-building skills and a genuine interest in understanding customer challenges before offering solutions. * Commercial awareness, good organisational skills and the ability to manage your own territory with support from the wider team. * A proactive approach, comfortable creating opportunities and maintaining momentum. Personal Attributes * Proactive, curious and motivated by creating opportunities. * Takes ownership, builds relationships and delivers results. * Thrives in a fast-paced, growing business and enjoys making a visible impact. * Willingness to travel extensively across the Southeast territory. SUCCESS IN THIS ROLE WILL LOOK LIKE: Within your first 30 days * Building strong internal relationships, developing a deep understanding of Cyted's technology, commercial strategy and customer landscape, and confidently communicating our clinical and economic value proposition. Within your first 60 days * Establishing trusted relationships with key healthcare stakeholders, actively progressing opportunities within your territory and confidently managing the sales process with increasing independence. Within your first 90 days * Independently driving new business opportunities, building a healthy sales pipeline, progressing customers towards implementation and making a visible contribution to Cyted's US commercial growth. BENEFITS  Financial & Retirement Benefits: * 401(k) Safe Harbor Plan with employer match: * Dollar-for-dollar match on the first 1% * 50 cents on the dollar up to 6% * Automatic enrolment after 2 months * Equity Participation: Share grants subject to board approval, giving you a stake in our mission and long-term growth. Health & Insurance Coverage: * Access to the company's medical insurance with company contributions of up to $1000/month * Access to self-pay vision and dental insurance options * Life Insurance: 3x your annual base earnings, employer-paid * Long-Term Disability (LTD): 60% of base salary up to $10,000/month * Short-Term Disability (STD): 60% of salary up to $2,500/week for up to 13 weeks * Employee Assistance Program (EAP): Full access to our EAP platform including courses and resources to support your wellbeing. Leave & Time Off: * 20 vacation days per year * 9 paid sick days * 8 paid holidays * 3 floating holiday days * 2 personal holiday days * Parental Leave: * 6 weeks fully paid primary caregiver leave * 2 weeks fully paid secondary caregiver leave * Holiday Purchase Scheme: Buy up to 5 extra vacation days per year. Learning, Development & Culture: * Annual CPD Allowance: $1,000 per year for professional development activities relevant to your role. * Regular Company Events: Including summer and holiday parties, team socials, and more.