Software Engineer (Inference Platform), London

Isomorphic Labs

Isomorphic Labs is applying frontier AI to help unlock deeper scientific insights, faster breakthroughs, and life-changing medicines with an ambition to solve all disease. The future is coming. A future enabled and enriched by the incredible power of machine learning. A future in which diseases are curtailed or cured starting with better and faster drug discovery.  Come and be part of an interdisciplinary team driving groundbreaking innovation and play a meaningful role in contributing towards us achieving our ambitious goals, while being a part of an inspiring and collaborative culture. The world we want tomorrow is the one we’re building today. It starts with the culture at this company. It starts with you.    ABOUT ISO Isomorphic Labs (IsoLabs) was launched in 2021 to advance human health by building on and beyond the Nobel-winning AlphaFold system. Since then, our interdisciplinary team of drug discovery experts and machine learning specialists has built powerful new predictive and generative AI models that accelerate scientific discovery at digital speed. Our name comes from the belief that there is an underlying symmetry between biology and information science. By harnessing AI’s powerful capabilities, we can use it to model complex biological phenomena to help design novel molecules, anticipate how drugs will perform and develop innovative medicines to treat and cure some of the world’s most devastating diseases. We have built a world-leading drug design engine comprising AI models that are capable of working across multiple therapeutic areas and drug modalities. We are continually innovating on model architecture and developing cutting-edge capabilities to advance rational drug design. Every day, and with each new breakthrough, we’re getting closer to the promise of digital biology, and achieving our ambitious mission to one day solve all disease with the help of AI.   Your Impact We are building the largest foundation models in biotech and applying them immediately to cure disease. You will play a pivotal role in ensuring the reliability and scalability of the foundations that make this possible. As a Principal Engineer, you will lead the efforts to harden our systems, ensuring our groundbreaking AI is built on an unshakeable base, working closely with the research team and the Applied ML teams to ensure the infrastructure is stable, reliable and can operate with more data and larger models as we grow.  What You Will Do * Develop and operate our inference platform, serving fleets of cutting-edge machine learning models to scientific applications. * Design strategy and build roadmaps for maturing the platform. * Architect and optimize our next-generation inference services. You will solve core scaling limits, ensuring high-throughput performance and feature parity across our model serving stack. * Contribute to core technical decisions on tooling and architectural design while partnering with science, product, and operations teams to align infrastructure with biotech R&D cycles. * Deliver high-quality and well-tested user-focused features. Skills and Qualifications Essential: * Proven experience in architecting and managing large-scale AI/ML workloads in a production environment. * Expertise in cloud compute design, specifically within Google Cloud Platform (GCP). * Orchestration: Significant experience deploying and managing complex workloads within Kubernetes (GKE). * Professional familiarity with NVIDIA GPU generations and the intricacies of high-performance compute. * Strong programming skills and a "reliability-first" approach to software development. Nice to Have: * A career history that spans both ML Software Engineering and Infrastructure SRE roles. * Experience leading multi-disciplinary projects and navigating complex stakeholder requirements in a fast-paced environment. * Familiarity with workload scheduling, ML efficiency research, and hardware benchmarking. * Experience with Google TPU generations and specialized ML-driven R&D cycles. CULTURE AND VALUES We are guided by our shared values. It's not about finding people who think and act in the same way. These values help to guide our work and will continue to strengthen it.  Thoughtful Thoughtful at Iso is about curiosity, creativity and care. It is about good people doing good, rigorous and future-making science every single day. Brave Brave at Iso is about fearlessness, but it’s also about initiative and integrity. The scale of the challenge demands nothing less. Determined Determined at Iso is the way we pursue our goal. It’s a confidence in our hypothesis, as well as the urgency and agility needed to deliver on it. Because disease won’t wait, so neither should we. Together Together at Iso is about connection, collaboration across fields and catalytic relationships. It’s knowing that transformation is a group project, and remembering that what we’re doing will have a real impact on real people everywhere. CREATING AN EXTRAORDINARY COMPANY We believe that to be successful we need a team with a range of skills and talents. We're building an environment where collaboration is fundamental, learning is shared and every employee feels supported and able to thrive. We value unique experiences, knowledge, backgrounds, and perspectives, and harness these qualities to create extraordinary impact. We are committed to equal employment opportunities regardless of sex, race, religion or belief, ethnic or national origin, disability, age, citizenship, marital, domestic or civil partnership status, sexual orientation, gender identity, pregnancy or related condition (including breastfeeding) or any other basis protected by applicable law. If you have a disability or additional need that requires accommodation, please do not hesitate to let us know. HYBRID WORKING It’s hugely important for us to share knowledge and build strong relationships with each other, and we find it easier to do this if we spend time together in person. This is why we follow a hybrid model, and would require you to be able to come into the office 3 days a week (currently Tuesday, Wednesday, and one other day depending on which team you’re in). If you have additional needs that would prevent you from following this hybrid approach, we’d be happy to talk through these if you’re selected for an initial screening call. Please note that when you submit an application, your data will be processed in line with our privacy policy. >> Click to view other open roles at Isomorphic Labs

PhysicsX

ABOUT US PhysicsX is a deep-tech company with roots in numerical physics and Formula One, dedicated to accelerating hardware innovation at the speed of software. We are building an AI-driven simulation software stack for engineering and manufacturing across advanced industries. By enabling high-fidelity, multi-physics simulation through AI inference across the entire engineering lifecycle, PhysicsX unlocks new levels of optimization and automation in design, manufacturing, and operations — empowering engineers to push the boundaries of possibility. Our customers include leading innovators in Aerospace & Defense, Materials, Energy, Semiconductors, and Automotive. THE ROLE PhysicsX is a deep-tech company with roots in numerical physics and Formula One, dedicated to accelerating hardware innovation at the speed of software. We are building an AI-driven simulation software stack for engineering and manufacturing across advanced industries. By enabling high-fidelity, multi-physics simulation through AI inference across the entire engineering lifecycle, PhysicsX unlocks new levels of optimization and automation in design, manufacturing, and operations, empowering engineers to push the boundaries of possibility. Our customers include leading innovators in Aerospace, Materials, Energy, Semiconductors, and Automotive. THE ROLE PhysicsX is building a platform that enables Data Scientists and Simulation Engineers to build, train, and deploy Deep Physics Models. Our platform serves multiple tenants across highly regulated industries, making robust identity, access control, and operational visibility foundational to everything we do. We're looking for a Senior Software Engineer to join our Core Services team, the team building the foundational primitives that gives our customers superpowers they've never had before. For decades, engineers have been trapped using siloed, rigid tools from the 90s. We're changing that by enabling secure, permissioned collaboration at the frontier of AI. You'll design and build the enterprise grade systems that make this possible. From fine-grained permissions to instrumentation, you'll create the primitives that every product across PhysicsX adopts, ensuring every user, service, and agentic workflow is securely identified, correctly scoped, and fully observable. You'll own the infrastructure that keeps our platform trustworthy, transparent, and ready for the future of manufacturing and engineering. WHAT YOU WILL DO * Design and implement authentication and authorisation systems, including identity provider integrations, token management, session handling, and SSO flows. * Architect and build fine-grained role-based and attribute-based access control (RBAC/ABAC) models that scale across multi-tenant environments. * Own the platform's permissions layer end-to-end: from policy definition and enforcement through auditing and compliance reporting. * Build and maintain telemetry infrastructure distributed tracing, structured logging, metrics collection, and alerting, to provide deep observability across services and environments. * Define and enforce security standards across APIs and services, including schema governance, data segregation, and least-privilege access patterns. * Design and implement identity and access patterns for AI agents, including MCP authentication, agent impersonation flows, and system account models that allow agents to act securely on behalf of users in a regulated, multi-tenant environment. * Contribute to the design of multi-service architectures, ensuring authentication and authorisation concerns are cleanly integrated and consistently enforced across both human and agentic workflows. * Drive best practices in CI/CD, automated testing, observability, and infrastructure-as-code. Build and maintain deployment pipelines, including zero-downtime and multi-service deployments. * Author and review Technical Decision Records. Participate in technology reviews to evaluate and adopt new tools and approaches. * Mentor junior and mid-level engineers, facilitate technical discussions, and build consensus around architectural decisions. WHAT YOU BRING TO THE TABLE * A passion for the craft, you're driven by engineering excellence and committed to fostering that culture across the team. * Strong software engineering foundations, solid grasp of algorithms, data structures, and system design. You write clean, maintainable, testable code and have strong command of Golang and Python. * Authentication and identity expertise, hands-on experience building or integrating identity and access management systems (e.g., Keycloak, Auth0, Okta). Deep understanding of OAuth 2.0, OIDC, SAML, and token-based authentication flows. Ability to effectively leverage cloud provider IAM systems (e.g., AWS IAM, GCP IAM, Azure AD). * Authorisation and permissions design, proven experience implementing RBAC, ABAC, or policy-as-code frameworks (e.g., OPA/Rego, Cedar) in production multi-tenant systems. * Telemetry and observability, experience designing and operating metrics, tracing, and logging pipelines (e.g., OpenTelemetry, Prometheus, Grafana, Jaeger). You understand what it takes to make distributed systems genuinely observable. * Kubernetes and GitOps, strong working knowledge of Kubernetes and ArgoCD, including deploying, managing, and troubleshooting services in production clusters. * API and service design maturity, experience designing multi-service systems with attention to schema governance, forward compatibility, and secure data access patterns. Proven ability to develop schema drift mitigation strategies with minimal impact to dependent clients (e.g., forward-compatible schemas, ACLs, ambassador sidecars). * Agent governance awareness, understanding of how identity and permissions extend to agentic systems, including MCP auth, impersonation, system accounts, and scoped token delegation. * Security awareness, familiarity with threat modelling, secure coding practices, and participating in security testing and compliance workflows. * CI/CD and deployment expertise, hands-on experience building and optimising CI/CD pipelines, including multi-service and zero-downtime deployments across numerous customer environments. * Communication and collaboration, excellent communication skills to work across teams, understand requirements from research scientists and product stakeholders, and translate them into technical specifications. * AI-native mindset, you follow the frontier of agentic systems and AI tooling. You naturally think about how infrastructure needs to evolve when agents, not just humans, are the consumers of your APIs and services. You actively use AI coding tools (e.g., Copilot, Cursor, Claude Code) in your daily workflow and see them as a force multiplier, not a novelty. * Incremental mindset, you work in small steps toward larger goals, driving change through continuous improvement rather than massive redesigns. You can zoom in on details and zoom out to see the big picture. IDEALLY * Polyglot programming, deep expertise in Python and Golang, with exposure to other languages such as Rust or C++. * Advanced Kubernetes, ability to leverage resources that extend the Kubernetes API (e.g., CRDs, Operators) and infrastructure configuration tools (Crossplane, Helm charts). * Infrastructure flexibility, understanding of what it takes to build software that runs in cloud, on-premises, and air-gapped environments. * Advanced testing, experience with fuzzing, deterministic simulation testing, or fault injection in production systems. What we offer Build what actually matters Help shape an AI-native engineering company at a formative stage, tackling problems that genuinely matter for industry and society. This is work with real-world impact - and something you can be proud to stand behind. Learn alongside exceptional people Work with a high-caliber, collaborative team of engineers, scientists, and operators who care deeply about doing great work, and about helping each other get better. We come from diverse backgrounds, but we share a commitment to operating at the highest level and addressing some of the most complex challenges out there. If you’re ambitious, thoughtful, and driven by impact, you’ll feel at home. Influence over hierarchy We operate with a flat structure: good ideas win - wherever they come from. Questioning assumptions and challenging the status quo isn’t just welcomed, it’s expected. Sustainable pace, long-term ambition Building meaningful technology is a marathon, not a sprint. We believe in balancing focused, ambitious work with a life beyond it. Our hybrid model blends time together in our Shoreditch office with work-from-home days, giving you the flexibility to work sustainably while staying connected in person. And it doesn’t stop there … 🚀 Equity options - share meaningfully in the company you’re helping to build. 🏦 10% employer pension contribution - because investing in future matters. 🍽️ Free office lunches - to keep you energised and focused. 👶 Enhanced parental leave - 3 months full pay paternity and 6 months full pay maternity leave, to provide extra flexibility during the moments that matter most. 🍼 YellowNest nursery scheme - to help working parents manage childcare costs. ☀️ 25 days of Annual Leave (+ Public Holidays) - because taking time to rest matters. 🏥 Private medical insurance - 100% employee cover, giving you complete peace of mind. 💪 Wellhub Subscription - gain access to thousands of gyms, classes and wellness apps, supporting both physical and mental wellbeing. 👀 Eye tests - because good work depends on good health. 📈 Personal development - dedicated support for learning, development, and leveling up over time. 💛 Employee Assistance Programme (EAP) - confidential wellbeing support, available whenever you need it. 🚲 Bike2Work scheme and 🚆 Season ticket loan - to make getting to work easier and greener. 🚗 Octopus EV salary sacrifice - for a simpler, more sustainable way to drive electric. 🔎 Watch this space, we’re continuing to build this as we grow…   We value diversity and are committed to equal employment opportunity regardless of sex, race, religion, ethnicity, nationality, disability, age, sexual orientation or gender identity. We strongly encourage individuals from groups traditionally underrepresented in tech to apply. To help make a change, we sponsor bright women from disadvantaged backgrounds through their university degrees in science and mathematics.    We collect diversity and inclusion data solely for the purpose of monitoring the effectiveness of our equal opportunities policies and ensuring compliance with UK employment and equality legislation. This information is confidential, used only in aggregate form, and will not influence the outcome of your application.

Winton

ABOUT WINTON Winton is a research-based investment management company with a specialist focus on statistical and mathematical inference in financial markets. The firm researches and trades quantitative investment strategies, which are implemented systematically via thousands of securities, spanning the world's major liquid asset classes. Founded in 1997 by David Harding, Winton today manages assets for some of the world’s largest institutional investors. We employ ambitious professionals who want to work collaboratively at the leading edge of investment management. ----------------------------------------------------------------------------------------------------------------------------------   We are seeking a highly capable Senior Software Engineer to help design, build and evolve resilient, event-driven, cloud-distributed systems. This role is ideal for an engineer who combines deep technical expertise, strong computer science fundamentals, and commercial awareness - someone who not only understands how systems work, but what they are meant to do and why. The role requires a constructive, can-do approach and the ability to operate effectively in a fast-paced setting. You will work across the full engineering lifecycle from system architecture and data modelling to implementation, testing and operational excellence. You will be encouraged to use modern AI-assisted tooling and continuously improve our platforms, while maintaining a pragmatic balance between innovation and delivery. You will be part of a friendly and collaborative broader team responsible for post-trade and reporting software development. The role involves working primarily in the Client Operations space but also directly with business functions across the firm to understand requirements, design and implement solutions. As well as project work, there are regular allocated windows of opportunity for small enhancements for both the business and technology. Your responsibilities will include:  •    Design, evolve and maintain distributed, event-driven systems with high reliability, scalability and observability •    Contribute to technical strategy and long-term platform direction •    Write high-quality, efficient and maintainable code with accompanying automated tests and documentation across UI, services and data storage layers •    Continuously improve existing services, libraries and shared components •    Ensure systems are operable, measurable and resilient, including appropriate monitoring, alerting and failure-handling strategies •    Work closely with product and business stakeholders to translate high-level problems into thoughtful technical solutions •    Collaborate with team through active contribution in code reviews, knowledge-sharing and design discussions •    Build domain knowledge in business and technology areas •    Evaluate new technologies pragmatically •    Contribute to CI/CD pipelines, tooling and infrastructure-as-code What we are looking for: •    A bachelor's or master's degree in a STEM subject •    5+ years of full-time professional software development experience •    Proven experience building and maintaining cloud-distributed, event-driven or microservices-based systems written in enterprise-grade backend technologies such as C#/.NET (preferred) •    Strong computer science fundamentals •    Excellent engineering discipline: clean code, meaningful abstractions, test automation, documentation and version control best practice •    Natural curiosity and enthusiastic about using AI-assisted development tools and integrating them into daily workflow •    Keen interest in keeping aware of latest technologies and a measured approach for adopting them •    Comfortable problem solving across multiple technologies and business domains •    Collaborative nature and ability to work in a team e.g. partnering with business users and technologists •    Ability to have constructive technical discussions What would be useful: •    An interest or experience with Angular and Typescript •    Familiarity with performance-tuning PostgreSQL and/or MSSQL •    Experience in financial services Technologies we use:  •    Web: Angular, TypeScript •    Server-side: C# •    Data: MSSQL, PostgreSQL •    Cloud: AWS •    Deployment: Docker, Kubernetes   ---------------------------------------------------------------------------------------------------------------------------------- EQUAL OPPORTUNITY WORKPLACE We are proud to be an equal opportunity workplace. We do not discriminate based upon race, religion, color, national origin, sex, sexual orientation, gender identity/expression, age, status as a protected veteran, status as an individual with a disability, or any other applicable legally protected characteristics.