
NLC Health Ventures · Nijmegen
CEO (GENE THERAPY) XTRNA Location: Netherlands preferred, Europe-based with regular travel to Nijmegen Commitment: ~80% (approximately) Compensation: Primaril...
Location: Netherlands preferred, Europe-based with regular travel to Nijmegen
Commitment: ~80% (approximately)
Compensation: Primarily equity-based, modest base salary until fundraising
Seniority: Founder/ leadership
XtRNA Bio is a pioneering biotechnology company redefining how we treat rare genetic diseases through transfer RNA (tRNA)
therapeutics. Originating from groundbreaking research at Radboud University and founded in collaboration with NLC Health
Ventures, XtRNA Bio is translating cutting-edge RNA biology into a new class of medicines that repair disease at its molecular
root.
The lead program targets Charcot-Marie-Tooth disease type 2D (CMT2D), a severe neuromuscular disorder caused by mutations in the
GARS1 gene. These mutations interfere with how motor neurons use tRNAs to make essential proteins, leading to progressive nerve
damage. XtRNA Bio’s AAV-mediated tRNA therapy restores normal protein synthesis, directly addressing the underlying cause of
disease. Preclinical studies have demonstrated strong proof of concept, showing potential to halt or even reverse
neurodegeneration.
While CMT2D is the initial focus, the tRNA platform has broad potential. Through two complementary approaches, elevating
disease-relevant tRNAs and engineering suppressor tRNAs for nonsense mutations, it can target a wide range of genetic diseases
caused by translational errors. This dual-modality approach places us among a select few companies globally advancing tRNA as a
therapeutic modality.
Supported by non-dilutive funding from the CMT Research Foundation and collaborations with world-leading scientists in the
Netherlands and Germany, XtRNA Bio is now advancing toward IND-enabling studies. With strong science, early validation, and a
mission-driven culture, XtRNA is building a biotech platform poised to transform RNA medicine, and bring new hope to patients with
currently untreatable genetic diseases.
The CEO of XtRNA Bio will lead the company’s mission to transform advanced RNA science into therapies for rare genetic diseases.
You will guide the venture from research to clinical development, shape its strategy, and drive the fundraising needed to achieve
key milestones.
This role calls for a leader who can unite scientific vision with business execution. You will inspire a high-performing team,
build strategic partnerships, attract investors, and position XtRNA Bio as a pioneering force in RNA medicine.
As CEO of XtRNA Bio, you will provide strategic and operational leadership to advance our pioneering tRNA therapeutic platform
from research toward clinical development.
expanding the broader tRNA platform
This role calls for a leader who can unite scientific insight, strategic execution, and purpose-driven leadership to position
XtRNA Bio at the forefront of RNA-based medicine.
To succeed as CEO of XtRNA Bio, you will bring a rare combination of scientific understanding, strategic leadership, and
entrepreneurial drive.
Qualifications
equivalent) is an advantage
rare disease)
pharmaceutical companies.
genetic disease mechanisms
If you are driven by the opportunity to transform pioneering RNA science into therapies that change lives, we invite you to shape
the future of XtRNA Bio with us.
NLC Health Ventures is a leading healthtech and biotech innovation platform based in Amsterdam, combining venture building and
fund management across Europe and North America. With 40-45 employees, NLC manages four captive funds investing in ventures from
pre-seed to Series B-C, and is fundraising for a fifth fund. The funds have a diverse LP base and are invested in over 70
companies. NLC values a collaborative, open, and impact-driven culture, where team members’ ideas and contributions truly matter.
About Repli5: Repli5 is a small Swedish startup based in Gothenburg that specializes in bringing Generative AI to computer vision applications. Our technology, called RealSim, leverages gen AI to bridge the gap between synthetic data and reality. This is particularly useful for creating accurate, realistic training data for computer vision models, essential in developing solutions for industrial robotics, autonomous drones, and select automotive applications. Our technology is also capable of enhancing real-world images by introducing extensive weather and lighting variations, which significantly increases the robustness of downstream computer vision models. We are now packaging this tech into a platform service built for computer vision engineers. The Opportunity: Shaping the Future of AI Perception We're looking for an experienced Machine Learning Engineer with a deep background in computer vision and generative AI. You’ll be part of a team developing workflows that generate realistic, diverse, and highly controllable synthetic image data using state-of-the-art tools like Stable Diffusion, LoRA, and ControlNet. These workflows will be adapted and applied to our new platform and your work will thus directly impact Repli5’s business and the performance and robustness of real-world AI systems—from self-driving cars to industrial automation. What You’ll Do (Key Responsibilities) Develop and fine-tune generative AI pipelines (e.g., Stable Diffusion, ControlNet, LoRA) for synthetic image generation. Design and implement machine learning workflows to generate structured, photorealistic datasets. Collaborate with 3D artists and simulation engineers to align ML models with physical environments and sensor setups. Work closely with customers in automotive, robotics, and aerospace to deliver tailored datasets. Optimize generation systems for scalability, quality, and speed using tools like ComfyUI or custom pipelines. Who You Are (Qualifications) The Essentials: MSc or PhD in Computer Vision, Machine Learning, or related field with 3+ years of hands-on experience with deep learning frameworks (e.g., PyTorch, TensorFlow). Extensive experience with state-of-the-art image generation models (GAN, Diffusion, Transformers) Exploring Mindset: Experience exploring workflows with generative AI models (especially diffusion-based) and a strong passion for reading and applying new research papers. Toolset Curiosity (Big Plus!): Familiarity with tools like LoRA, ControlNet, ComfyUI, or custom workflows around Stable Diffusion. Domain Knowledge (Big Plus!): Strong understanding of synthetic data generation and its role in training perception systems. Practitioner: A track record of deploying ML systems in domains like industrial automation, defense, or automotive. The Startup Gene: You excel in fast-paced, ambiguous environments where you can take initiative and work independently. A Team Player: A problem-solving intellect with a team player spirit and a positive can-do attitude. What We Offer A competitive compensation package. Flexibility and work-life balance. Challenging tasks that are at the forefront of technology. The autonomy to make major technical decisions and influence the product direction. An international, caring culture where it is natural to both ask for and offer help. Flexible working hours and the possibility to work from home some days a week. Fun at work. Recruitment Process Application Review First Interview (1-1 with COO) - More about you. This is our chance to learn who you are and what you bring to the table. Technical interview (with 2-3 from the Repli5 team). You're given a technical problem similar to a customer request and you are expected to present how you would solve this (but not present the actual solution). This is followed by general technical questions Final stage is a sync with the CEO.
About Repli5 Repli5 is a Swedish startup based in Gothenburg that specializes in bringing Generative AI to computer vision applications. Our technology, called RealSim, leverages gen AI to bridge the gap between synthetic data and reality. This is particularly useful for creating accurate, realistic training data for computer vision models, which is essential in developing solutions for industrial robotics, autonomous drones, smart factories, and select automotive applications. Our technology is also capable of enhancing real-world images by introducing extensive weather and lighting variations, which significantly increases the robustness of downstream computer vision models. We are now packaging this tech into a platform service built for computer vision engineers. The Opportunity: Build the Engine of our Future We are looking for a highly driven Founding Software Product Engineer - Repli5 Platform to take the reins on our core cloud platform. This is a rare "greenfield" opportunity: you will be architecting and building out the platform from the ground up, allowing users to effortlessly generate computer vision training datasets. As a pivotal early member of our startup, you won't just be writing code—you will lead our platform development. You will sit at the intersection of our users, our 3D artists, and our Machine Learning engineers, translating complex generative AI capabilities into a seamless, scalable user experience. If you love the autonomy of a startup, thrive on making high-level architectural decisions, and want to build a product that directly impacts the future of autonomous systems and robotics, this is the role for you. What You Will Do (Key Responsibilities) Architect & Build: Lead the end-to-end full-stack development of our user-facing cloud platform, owning the technical roadmap and tech stack decisions. Product Lead: Lead the development of the platform product and ensure we are building features that solve real problems for our clients in robotics, drones, and manufacturing. Design for Flexibility: Create a robust architecture that thrives as a cloud-native application today, but is adaptable enough to be packaged for strict on-premise enterprise deployments tomorrow. Bridge the Gap: Work closely with our Software, Machine Learning, and 3D teams. You don't need to be an ML scientist, but you will integrate generative AI features and distributed training pipelines into the platform. Drive Engineering Culture: Set the standard for clean code, scalable architecture, and platform security as we grow the team around you. Who You Are (Qualifications) The Essentials: Minimum of 5 years of proven experience in full-stack software development with strong programming skills in modern frameworks (e.g., SvelteKit/React for frontend; Python/Node.js/Go for backend). Cloud & Infrastructure Guru: Deep experience architecting and deploying cloud platforms and practical knowledge of containerization/orchestration for both cloud and on-prem environments, as well as DevOps skills and experience in GPU-based services. Product Mindset: You have experience with, or a strong appetite for, Product Management/Product Ownership. You care just as much about why you are building something as how you are building it. The Startup Gene: You excel in fast-paced, ambiguous environments where you can take initiative and work independently. Cross-Disciplinary Curiosity (Big Plus!): A strong interest in or exposure to 3D creation (e.g., Unreal Engine, Blender) and/or Machine Learning (specifically Generative AI or Stable Diffusion). Understanding these domains will give you a massive advantage in collaborating with our specialized team members! A Team Player: A problem solving intellect with a team player spirit and a positive can-do attitude. What We Offer A competitive salary, pension, insurances and Stock Options. Healthy work-life balance. Challenging tasks that are at the forefront of technology. The autonomy to make major technical decisions and influence the product direction. An international, caring culture where it is natural to both ask for and offer help. Flexible working hours and the possibility to work from home some days a week. Fun at work. Recruitment Process Application Review First Interview (1-1 with COO) - More about you. This is our chance to learn who you are and what you bring to the table. Technical interview (with 2-3 from the Repli5 team). You're given a technical problem related to the position and you are expected to present how you would solve this. This is followed by general technical questions Final stage is a sync with the CEO.
STELLE ZU BESETZEN AB: * Interesse an nachhaltigen Technologien und zukunftsorientierten Themen * Engagement, Eigeninitiative und die Motivation, Dinge aktiv voranzubringen * Eine strukturierte, selbstständige und lösungsorientierte Arbeitsweise * Teamfähigkeit sowie eine klare und offene Kommunikation * Flexibilität und die Bereitschaft, sich in neue Aufgabenbereiche einzuarbeiten * Offenheit für Veränderungen und Freude daran, in einem dynamischen Umfeld zu arbeiten HIER BRINGEN SIE SICH EIN Ist für Sie keine passende Stelle dabei? Inspirieren Sie uns und lassen Sie uns wissen welchen Beitrag Sie leisten könnten, um mit PYREG die Welt ein Stück sauberer und besser zu machen. Wir sind ständig auf der Suche nach klugen Köpfen, die die Entwicklung von PYREG weiter voran treiben. Wenn auch nicht gleich eine passende Position frei ist, nehmen wir Sie gerne in unseren Talent Pool auf und kommen auf Sie zu, sobald sich etwas passendes ergibt. Fordern Sie uns hierzu bitte einmal explizit schriftlich auf, damit wir Ihre Unterlagen länger als gewöhnlich speichern dürfen. DAS BRINGEN SIE MIT DAS BIETEN WIR * Attraktive Vergütung, Sozialleistungen und einen unbefristeten Arbeitsvertrag * Abwechslungsreiche Aufgabengebiete mit internationalem Hintergrund * Entwicklungs- und Weiterbildungsmöglichkeiten in einer Zukunftsbranche * Teamorientierte Arbeitsatmosphäre in einem kollegialen Umfeld * Betriebliche Altersvorsorge * Bikeleasing via JobRad * Getränke gehen aufs Haus * Corporate Benefits PERSONAL Bewerben Sie sich bei uns über das Bewerbungsformular, mit Ihren vollständigen Bewerbungsunterlagen (mit Gehaltswunsch und frühestmöglichem Eintrittstermin). Das HR-Teams steht Ihnen auch für weitere Fragen unter Tel. +49 6747 95388-0 gerne zur Verfügung. Wir freuen uns darauf, Sie kennenzulernen.