Drug Discovery Program leader

Clinical Program Manager, Cambridge, MA

Isomorphic Labs

Isomorphic Labs is applying frontier AI to help unlock deeper scientific insights, faster breakthroughs, and life-changing medicines with an ambition to solve all disease. The future is coming. A future enabled and enriched by the incredible power of machine learning. A future in which diseases are curtailed or cured starting with better and faster drug discovery.  Come and be part of an interdisciplinary team driving groundbreaking innovation and play a meaningful role in contributing towards us achieving our ambitious goals, while being a part of an inspiring and collaborative culture. The world we want tomorrow is the one we’re building today. It starts with the culture at this company. It starts with you.    ABOUT ISO Isomorphic Labs (IsoLabs) was launched in 2021 to advance human health by building on and beyond the Nobel-winning AlphaFold system. Since then, our interdisciplinary team of drug discovery experts and machine learning specialists has built powerful new predictive and generative AI models that accelerate scientific discovery at digital speed. Our name comes from the belief that there is an underlying symmetry between biology and information science. By harnessing AI’s powerful capabilities, we can use it to model complex biological phenomena to help design novel molecules, anticipate how drugs will perform and develop innovative medicines to treat and cure some of the world’s most devastating diseases. We have built a world-leading drug design engine comprising AI models that are capable of working across multiple therapeutic areas and drug modalities. We are continually innovating on model architecture and developing cutting-edge capabilities to advance rational drug design. Every day, and with each new breakthrough, we’re getting closer to the promise of digital biology, and achieving our ambitious mission to one day solve all disease with the help of AI.   CLINICAL PROGRAM MANAGER, CAMBRIDGE MA Isomorphic Labs (IsoLabs) is developing and applying frontier AI to help unlock deeper scientific insights, faster breakthroughs, and life-changing medicines. The company’s ambitious mission is to one day solve all disease. IsoLabs has built multiple cutting-edge AI models that power our unified drug design engine, which can tackle a broad spectrum of disease areas and modalities. This breakthrough technology will transform how we design new drug candidates and bring new potential medicines to patients. Come and be part of an interdisciplinary team driving groundbreaking innovation. You will play a meaningful role in achieving our ambitious goals, while being a part of an inspiring and collaborative culture. Together, let’s build the future of medicine at Isomorphic Labs. ABOUT ISO Isomorphic Labs was launched in 2021 to advance human health by building on and beyond the Nobel prize-winning AlphaFold system. Since then, our interdisciplinary team of drug discovery experts and machine learning specialists has built powerful new predictive and generative AI models that accelerate scientific discovery at digital speed. Our name comes from the belief that there is an underlying symmetry between biology and information science. By harnessing AI’s powerful capabilities, we can use it to model complex biological phenomena to help design novel molecules, anticipate how drug candidates will perform in the clinic and develop medicines to treat and cure some of the world’s most devastating diseases. At IsoLabs, we are committed to leveraging state-of-the-art AI to advance precision medicine paradigms and establish new benchmarks for both efficacy and safety by consistently delivering the optimal treatments to the appropriate patients at precisely the right time, which we expect to significantly enhance our overall probability of success.  Since our founding, we have grown a world-class interdisciplinary team led by founder and CEO Sir Demis Hassabis and President Max Jaderberg. We have built strategic drug discovery collaborations with partners including Eli Lilly, Novartis and Johnson & Johnson, with the Novartis collaboration expanding in February 2025 to double its original scope. Our internal drug candidate pipeline consists of multiple programs across oncology and immunology.  In March 2025, IsoLabs raised $600 million in its first external funding round, led by Thrive Capital with participation from GV and Alphabet. In May 2026, IsoLabs raised $2.1 billion in a Series B financing round. This investment will power our world-leading AI drug design engine, scale our business globally and progress our drug candidate pipeline. The round was led by Thrive Capital, and includes participation from existing backers Alphabet and GV alongside new investors MGX, Temasek, CapitalG, and the UK Sovereign AI Fund, significantly expanding our global capital base.Isomorphic Labs is scaling globally, with headquarters in London and offices in Lausanne, Switzerland and a US base in Cambridge, Massachusetts. We continue to progress our internal candidate programs towards the clinic while advancing across a broad range of modalities including small molecules, molecular glues, peptides, and antibodies.  YOUR IMPACT  The experienced Clinical Program Manager will help to lead the transition of our internal programs from pre-IND to clinical trial execution. Reporting to the Program Lead, this critical role will work with the cross-functional global team to drive clinical trial execution, managing timelines, risks, budgets and vendor partnerships. They will leverage AI and emerging technologies to ensure efficient outcomes with a high probability of success.  WHAT YOU WILL DO  * Project planning and execution: Develop and own integrated project plans that track operational strategy, timelines, risks and dependencies across workstreams to ensure alignment between clinical objectives and company goals. * Cross-functional leadership and communication: Act as the central point of contact ensuring high performance and alignment among the cross-functional clinical trial team.  * Lead project team meetings ensuring effective information sharing, decision making and documentation. * Collaborate with preclinical program managers as well as AI/ML and data science teams to identify and implement new solutions to increase speed, scale and probability of success. * External Partnerships: Oversee and manage a network of external vendors, CROs, partners and collaborators including budgets, timelines and key deliverables. * Stakeholder Management: Provide regular updates to leadership and key stakeholders on clinical study execution and portfolio management. * Proactively and in real-time help teams to problem solve and identify issues that impact key deliverables, timelines and budgets.   SKILLS AND QUALIFICATIONS  ESSENTIAL: * You must have a proven track record of managing a clinical program from IND through late stage clinical development, within expected timelines and budgets. * Experience working cross functionally with key stakeholders internally as well as external vendors and collaborators. Excellence in building relationships in both settings. * Highly organized with experienced managing large budgets and complex interdependent timelines using project management tools. * Strong sense of urgency and accountability to operate in a fast-paced environment. * Flexibility to adapt to changing timelines and priorities. * Strong leadership and excellent communication skills. * Willingness and ability to motivate and hold accountable, interdisciplinary teams and vendors. Ensure on time and within budget execution. NICE TO HAVE: * Formal program management qualification (eg PMP) * Experience working as part of a global team across countries CULTURE AND VALUES We are guided by our shared values. It's not about finding people who think and act in the same way. These values help to guide our work and will continue to strengthen it.  Thoughtful Thoughtful at Iso is about curiosity, creativity and care. It is about good people doing good, rigorous and future-making science every single day. Brave Brave at Iso is about fearlessness, but it’s also about initiative and integrity. The scale of the challenge demands nothing less. Determined Determined at Iso is the way we pursue our goal. It’s a confidence in our hypothesis, as well as the urgency and agility needed to deliver on it. Because disease won’t wait, so neither should we. Together Together at Iso is about connection, collaboration across fields and catalytic relationships. It’s knowing that transformation is a group project, and remembering that what we’re doing will have a real impact on real people everywhere. CREATING AN EXTRAORDINARY COMPANY We believe that to be successful we need a team with a range of skills and talents. We're building an environment where collaboration is fundamental, learning is shared and every employee feels supported and able to thrive. We value unique experiences, knowledge, backgrounds, and perspectives, and harness these qualities to create extraordinary impact. We are committed to equal employment opportunities regardless of sex, race, religion or belief, ethnic or national origin, disability, age, citizenship, marital, domestic or civil partnership status, sexual orientation, gender identity, pregnancy or related condition (including breastfeeding) or any other basis protected by applicable law. If you have a disability or additional need that requires accommodation, please do not hesitate to let us know. HYBRID WORKING It’s hugely important for us to share knowledge and build strong relationships with each other, and we find it easier to do this if we spend time together in person. This is why we follow a hybrid model, and would require you to be able to come into the office 3 days a week (currently Tuesday, Wednesday, and one other day depending on which team you’re in). If you have additional needs that would prevent you from following this hybrid approach, we’d be happy to talk through these if you’re selected for an initial screening call. Please note that when you submit an application, your data will be processed in line with our privacy policy. >> Click to view other open roles at Isomorphic Labs

North America Head of Medical Affairs Operations & Excellence

Kyowa Kirin

Kyowa Kirin is a fast-growing global specialty pharmaceutical company that applies state-of-the-art biotechnologies to discover and deliver novel medicines in four disease areas: bone and mineral; intractable hematologic; hematology oncology; and rare disease.  A Japan-based company, our goal is to translate science into smiles by delivering therapies where no adequate treatments currently exist, working from drug discovery to product development and commercialization. In North America, we are headquartered in Princeton, NJ, with offices in California, North Carolina, and Mississauga, Ontario. Summary of Job: The North America Head of Medical Affairs Operations & Excellence is a senior leadership role responsible for advancing the strategic, operational, and organizational effectiveness of the North America Medical Affairs function. With regional accountability and strong partnership across Global Medical Affairs, this leader drives integrated planning, governance, resource optimization, performance management, and execution excellence to support the organization's scientific and business objectives. The role provides leadership and oversight for Medical Affairs operations and directly manages the North America Medical Affairs Project Management team. As a key member of the Medical Affairs leadership ecosystem, the Head of Medical Affairs Operations & Excellence partners closely with regional and global stakeholders to align priorities, enable cross-functional execution, optimize portfolio delivery, and foster a culture of continuous improvement, scalability, and operational rigor across the organization. Essential Functions: Medical Affairs Operations & Strategy Enablement * Lead the design, implementation, and continuous improvement of Medical Affairs operational models across North America. * Translate Medical Affairs strategy into integrated operational plans, timelines, and execution frameworks across therapeutic areas and assets. * Partner with North America Medical Affairs leadership to support annual planning, goal setting, prioritization, and resourcing decisions. * Enable effective execution across the Medical Affairs portfolio by driving clarity of roles, responsibilities, decision rights, and interdependencies. * Provide regional accountability for North America Medical Affairs systems and tools (e.g., planning, tracking, and performance management platforms), ensuring fit-for-purpose use, alignment with global standards, and continuous optimization. * Oversee North America Medical Affairs operating budgets, including planning, forecasting, tracking, and optimization of spend in partnership with Finance and Global Medical Affairs counterparts. * Oversee promotional/non-promotional review process Project Management & Execution Excellence * Oversee a team of Medical Affairs project managers responsible for planning and execution of key Medical Affairs initiatives, programs, and milestones. * Establish standardized project management methodologies, tools, and best practices across Medical Affairs. * Ensure consistent tracking, reporting, and escalation of risks, dependencies, and execution issues across the portfolio. * Drive on-time, high-quality delivery of Medical Affairs initiatives through strong governance and disciplined execution.  Governance, Processes & Ways of Working * Lead Medical Affairs governance forums and operating rhythms, including portfolio reviews, planning meetings, and leadership updates. * Establish and maintain clear processes for intake, prioritization, execution, and decision-making across Medical Affairs activities. * Partner with Regulatory, Legal, Compliance, and other functions to ensure Medical Affairs operations align with internal policies and external requirements. * Drive simplification and efficiency by identifying and addressing process gaps, redundancies, and operational pain points.  Performance Management & Insights * Define and implement performance metrics, dashboards, and reporting to track Medical Affairs execution, impact, and resource utilization. * Enable data-driven decision-making through clear insights into progress, risks, and outcomes. * Support continuous improvement by using performance insights to inform planning, prioritization, and operational enhancements. * People Leadership & Capability Building * Lead, develop, and mentor a team of Medical Affairs project managers, fostering a culture of accountability, collaboration, and operational excellence. * Build project management and operational capabilities across the Medical Affairs organization through training, coaching, and best practice sharing. * Support talent development, succession planning, and future capability needs as the portfolio and organization evolve.  Cross-Functional Leadership & Strategic Partnership * Serve as a strategic operational partner to the North America Medical Affairs Leadership Team, Therapeutic Area and Asset Leads, and Medical Affairs functional leaders. * Foster alignment, transparency, and effective execution across Medical Affairs, including Project Management, Scientific Communications, Medical Education, and Field Medical teams. * Partner closely with Clinical Development, HEOR, Regulatory Affairs, Commercial, Finance, Legal, and Compliance to enable integrated planning, decision-making, and execution. * Collaborate with the Global Medical Affairs Office Head and Global Medical Affairs Operations/Strategy counterparts to ensure alignment of regional priorities with global objectives and best practices. * Act as a key connector across functions and geographies, facilitating communication, managing interdependencies, and driving seamless execution of Medical Affairs initiatives.  Decision-Making Authority * Accountable for Medical Affairs operational frameworks, execution standards, and performance management across North America. * Authority to establish project management methodologies, tools, and reporting standards. * Operational escalation authority for execution risks, resource constraints, and cross-functional dependencies. * Input into Medical Affairs resourcing, prioritization, and organizational design decisions. Job Requirements: Education Bachelor's degree in Life Sciences, Business Administration, Project Management, or a related field required. Advanced degree in a scientific, clinical, or healthcare-related discipline strongly preferred (e.g., MD, PharmD, PhD, MSN, or equivalent).  Experience * Minimum of 12 years in the pharmaceutical/biotechnology industry, including at least 6 years within Medical Affairs. * Demonstrated leadership in Medical Affairs Operations, strategic planning, portfolio management, or enterprise project management functions. * Proven success leading project managers, operational teams, and/or matrixed organizations. * Track record of supporting Medical Affairs strategy development and execution across multiple therapeutic areas, assets, and stages of the product lifecycle. * Strong understanding of Medical Affairs governance, operating models, and cross-functional collaboration within a matrix environment. * Knowledge of evidence generation activities, including investigator-sponsored studies (ISS), collaborative research, medical publications, and real-world evidence initiatives. * Solid understanding of clinical development processes and the role of Medical Affairs in lifecycle management, scientific engagement, and brand strategy. * Demonstrated ability to lead portfolio prioritization, resource planning, governance, and performance management processes. * History of effective partnership with Clinical Development, Regulatory Affairs, HEOR, Commercial, Legal, Compliance, and Finance functions to drive integrated planning and execution. * Familiarity with global and regional organizational structures, including alignment of regional priorities with global strategies, processes, and governance frameworks. Technical Skills & Competencies * Strong understanding of Medical Affairs operating models, governance structures, and the role of Medical Affairs across the product lifecycle. * Demonstrated expertise in strategic planning, portfolio management, resource planning, and organizational prioritization within a complex matrix environment. * Advanced knowledge of Medical Affairs planning and execution, including evidence generation, scientific communications, medical education, field medical, and investigator-sponsored research activities. * Strong understanding of clinical development, regulatory requirements, compliance standards, and industry guidelines relevant to Medical Affairs operations. * Proven ability to establish and optimize operational processes, governance frameworks, performance metrics, and business planning capabilities that drive organizational effectiveness and scalability. * Exceptional leadership and stakeholder management skills, with the ability to influence and align diverse cross-functional and global stakeholders without direct authority. * Strong business acumen and strategic thinking, with the ability to translate organizational priorities into actionable operational plans and measurable outcomes. * Excellent communication and presentation skills, with the ability to effectively engage senior leaders and facilitate decision-making across complex organizations. * Strong analytical and problem-solving capabilities, including the use of data and performance insights to support decision-making, resource allocation, and continuous improvement initiatives. * Proficiency with business planning, project portfolio management, reporting, and collaboration tools; advanced proficiency in Microsoft Office applications, including PowerPoint and Excel. Physical Demands:  Normal office environment with prolonged periods of sitting and extensive computer use. For remote position, the incumbent's work schedule must provide sufficient overlap with Eastern Time (ET) business hours, as needed, to support meetings and collaboration with the Princeton, NJ headquarters   Working Conditions:  This position may be based in a hybrid work arrangement for incumbents located near Princeton, NJ, or as a remote position. For remote position, the incumbent is required to travel to the Princeton, NJ headquarters at least once per month and up to two (2) times per month, as business needs require. Each visit requires a minimum stay of four (4) consecutive business days. In addition to travel to the Princeton headquarters, the incumbent may be required to travel domestically and internationally up to 25% for business purposes.   Non-Technical Skills Ability to thrive in a fast-paced environment while managing ambiguity effectively. Strong work ethics are required. Passion for personal learning and professional development. Cultural sensitivity and adaptability within multinational organizations. Physical Demands:    The anticipated salary for this position will be $300,000 to $345,500.  The actual salary offered for this role at commencement of employment may vary based on several factors including but not limited to relevant experience, skill set, qualifications, education (including applicable licenses and certifications, job-based knowledge, location, and other business and organizational needs. The listed salary is just one component of the overall compensation package. At Kyowa Kirin North America we provide a comprehensive range of benefits including: * 401K with company match * Annual Bonus Program (Sales Bonus for Sales Jobs) * Generous PTO and Holiday Schedule which includes Summer and Winter Shut-Downs, Sick Days and, Volunteer Days * Healthcare Benefits (Medical, Dental, Prescription Drugs and Vision) * HSA & FSA Programs * Well-Being and Work/Life Programs * Life & Disability Insurance * Concierge Services * Long Term Incentive Program (subject to job level and performance) * Pet Insurance * Tuition Assistance * Employee Referral Awards The compensation and benefits information set forth in this posting applies to candidates hired in the United States. Candidates hired outside the United States will be eligible for compensation and benefits in accordance with their local market. KKNA and all of its employees have an obligation to act in accordance with the law and with integrity in all our operations and interactions It is the policy of Kyowa Kirin North America, Inc. to provide equal employment opportunity to all qualified persons without regard to race, religion, creed, color, pregnancy, sex, age, national origin, disability, genetic trait or predisposition, veteran status, marital status, sexual orientation or affection preference or citizenship status or any other category protected by law. When you apply to a job on this site, the personal data contained in your application will be collected and stored by Kyowa Kirin, Inc. (“Controller”), which is located at 510 Carnegie Center Dr. Princeton, NJ 08540 USA and can be contacted by emailing kkus.talentacquisition.8h@kyowakirin.com. Controller’s data protection officer can be contacted at usprivacyoffice@kyowakirin.com. Your personal data will be processed for the purposes of managing Controller’s recruitment related activities, which include setting up and conducting interviews and tests for applicants, evaluating and assessing the results thereto, and as is otherwise needed in the recruitment and hiring processes. Such processing is legally permissible under Art. 6(1)(f) of General Data Protection Regulation (EU) 2016/679 (“GDPR”) as necessary for the purposes of the legitimate interests pursued by the Controller, which are the solicitation, evaluation, and selection of applicants for employment.  Your personal data will be shared with Greenhouse Software, Inc., a cloud services provider located in the United States of America and engaged by Controller to help manage its recruitment and hiring process on Controller’s behalf. Accordingly, if you are located outside of the United States, your personal data will be transferred to the United States once you submit it through this site. The transfer will be made using appropriate additional safeguards under the standard contractual clauses approved by regulators for transfers of personal data outside the European Union. Your personal data will be retained by Controller as long as Controller determines it is necessary to evaluate your application for employment.  Under the GDPR, if you are located in the European Union, you have the right to request access to your personal data, to request that your personal data be rectified or erased, and to request that processing of your personal data be restricted. You also have the right to data portability, and to lodge a complaint with an EU supervisory authority. If you have any questions about our use of your data, you may contact us by email at usprivacyoffice@kyowakirin.com. RECRUITMENT & STAFFING AGENCIES Kyowa Kirin does not accept agency resumes unless contacted directly by internal Kyowa Kirin Talent Acquisition. Please do not forward resumes to Kyowa Kirin employees or any other company location; Kyowa Kirin is not responsible for any fees related to unsolicited resumes.

Machine Learning Scientist – Sequence Modelling

Relation Therapeutics

ABOUT RELATION Relation is an end-to-end biotech company developing transformational medicines, with technology at our core. Our ambition is to understand human biology in unprecedented ways, discovering therapies to treat some of life’s most devastating diseases. We leverage single-cell multi-omics directly from patient tissue, functional assays, and machine learning to drive disease understanding—from cause to cure. This year, we embarked on an exciting dual collaboration with GSK to tackle fibrosis and osteoarthritis, while also advancing our own internal osteoporosis program. By combining our cutting-edge ML capabilities with GSK’s deep expertise in drug discovery, this partnership underscores our commitment to pioneering science and delivering impactful therapies to patients. We are rapidly scaling our technology and discovery teams, offering a unique opportunity to join one of the most innovative TechBio companies. Be part of our dynamic, interdisciplinary teams, collaborating closely to redefine the boundaries of possibility in drug discovery. Our state-of-the-art wet and dry laboratories, located in the heart of London, provide an exceptional environment to foster interdisciplinarity and turn groundbreaking ideas into impactful therapies for patients. We are committed to building diverse and inclusive teams. Relation is an equal opportunities employer and does not discriminate on the grounds of gender, sexual orientation, marital or civil partnership status, gender reassignment, race, colour, nationality, ethnic or national origin, religion or belief, disability, or age. We cultivate innovation through collaboration, empowering every team member to do their best work and reach their highest potential. By joining Relation, you will become part of an exceptionally talented team with extraordinary leverage to advance the field of drug discovery. Your work will shape our culture, strategic direction and, most importantly, impact patients’ lives. THE OPPORTUNITY As a Machine Learning Scientist within the Rosalind team, you will design and apply advanced machine learning techniques to DNA and genetic data. This role is ideal for someone with a strong machine learning background and an interest in genetics. Your work will directly contribute to uncovering non-trivial associations between genetic variants and diseases, ultimately advancing therapeutic discovery. THE TEAM YOU WILL JOIN The Rosalind team aims to extract useful insights through representations of DNA, whether related to variants, genes or the regulatory mechanisms in between. Sitting at the forefront of ML for genomics, the team develops models that help uncover meaningful biological signals from DNA and turn them into foundations for our target discovery pipelines. The team also has a strong track record of publishing at major ML venues, including winning a Best Paper award for PatchDNA at the NeurIPS AI4D3 workshop and publishing recently in the main conference track at ICLR: https://iclr.cc/virtual/2026/poster/10011056. It’s an exciting opportunity to contribute to cutting-edge research, advance representation learning for DNA, and help build state-of-the-art models for understanding biology and disease. YOUR RESPONSIBILITIES * Develop and apply sequence modelling machine learning techniques to DNA sequences * Train, fine-tune and evaluate DNA sequence models for tasks including variant interpretation, gene discovery and regulatory modelling * Collaborate with computational and experimental scientists to generate and validate ML-driven hypotheses * Leverage large-scale external and internal datasets to build and adapt models for disease-focused applications * Design robust evaluations to measure model quality, biological relevance and translational value * Contribute to scientific innovation by applying the latest advances in machine learning and genomics. PROFESSIONALLY, YOU HAVE * A PhD in machine learning, computational biology, or a related field, or equivalent industrial experience * Demonstrated experience applying machine learning techniques to biological sequences or text * Proficiency in Python and at least one ML platform (e.g. PyTorch, TensorFlow) * Flexibility and the ability to tackle new challenges at the intersection of biology and machine learning. DESIRABLE KNOWLEDGE OR EXPERIENCE * Experience applying machine learning to biological sequences, including DNA or proteins * Strong understanding of transformers and their applications in biomedical research * Knowledge of lab-in-the-loop frameworks and integration of ML techniques with experimental data. PERSONALLY, YOU ARE * An inclusive leader and team player * A clear communicator * Driven by impact * Humble and eager to learn * Motivated and curious * Passionate about making a difference in patients’ lives Join us in this exciting role where your contributions will have a direct impact on advancing our understanding of genetics and disease risk, supporting our mission to bring transformative medicines to patients. Together, we’re not just doing research; we’re setting new standards in the field of machine learning and genetics. The patient is waiting! Relation is a committed equal opportunities employer. RECRUITMENT AGENCIES Please note that Relation does not accept unsolicited CVs from agencies. CVs should not be forwarded to our job aliases or employees. Relation Therapeutics will not be liable for any fees associated with unsolicited CVs.