Akelius Math AB · Sweden
Ansök om tjänsten "Postdoctor in single-cell genomics and imaging of kidney injury" hos Akelius Math AB via deras ansökningsportal....
Ansök om tjänsten "Postdoctor in single-cell genomics and imaging of kidney injury" hos Akelius Math AB via deras ansökningsportal.
The University of Gothenburg tackles society's challenges with diverse knowledge. 58 000 students and 6800 employees make the university a large and inspiring place to work and study. Strong research and attractive study programmes attract researchers and students from around the world. With new knowledge and new perspectives, the University contributes to a better future. https://web103.reachmee.com/ext/I005/1035/job?site=7&lang=UK&validator=9b89bead79bb7258ad55c8d75228e5b7&job_id=39310 Subject area Single-cell genomics and functional imaging of kidney epithelial injury Subject area description The project aims to develop and apply novel experimental methods to study functional heterogeneity in proximal tubular epithelial cells (PTECs) during kidney injury. By combining direct measurements of albumin reabsorption with single-cell transcriptomics, the project seeks to identify molecular programs underlying epithelial dysfunction and to discover targetable pathways relevant to kidney disease. Duties The successful candidate will lead experimental work across multiple PTEC injury models, including toxic, metabolic, inflammatory, and hypoxia–reoxygenation stress. Key tasks include functional uptake assays using fluorescently labelled albumin, cell and tissue imaging, preparation of single-cell RNA sequencing libraries, data generation from primary human PTECs and acute kidney slices, and close collaboration with computational researchers for downstream analysis. Validation of candidate pathways in tissue slices will be an additional component of the work. Eligibility The eligibility criteria for employing teaching staff are set out in Chapter 4 of the Higher Education Ordinance and in the Appointment Procedure for Teaching Posts at the University of Gothenburg. To be eligible for appointment as a postdoc, the applicant is required to have a doctoral degree, a doctoral degree in art or a foreign degree that is deemed to be equivalent to a doctoral degree. This eligibility requirement must be met before the employment decision is made. In the first instance, those who have completed their degree no more than three years prior to the end of the application period shall be considered. Those who have completed their degree more than three years prior to the end of the application period may also be considered in the first instance if special grounds exist. Special grounds relate to leave of absence due to illness, parental leave, commissions of trust within union organisations, service within the defence services or other similar circumstances, as well as clinical service or service/assignment relevant to the subject area. Assessment criteria The ideal candidates should have: PhD in Molecular or Cell Biology, or a related life science discipline Experience in cell-based assays and tissue culture Experience with molecular biology techniques (RNA extraction, qPCR, NGS library preparation) Experience with microscopy techniques, and analysis tools (e.g. Fiji) Knowledge of single-cell RNA sequencing methods Experience with functional assays in epithelial cells or kidney-related models Experience with FACS Experience analyzing high-dimensional biological data (Python) Ability to work independently, plan experiments, and troubleshoot High level of motivation, accuracy, and organizational skills Fluency in English Regulations for the evaluation of qualifications for academic positions are given in Chapter 4, Section 3 - 4 of the Higher Education Ordinance Employment The employment is full time and temporary, two years with the possibility of one year's extension, with placement at the Institute of Biomedicine. First day of employment as agreed. Selection process https://www.gu.se/en/work-at-the-university-of-gothenburg/how-to-apply-for-a-position Contact information If you have any questions about the position, please contact Dr. Joan Camuñas Soler: joan.camunas@gu.se Unions Union representatives at the University of Gothenburg can be found here: https://www.gu.se/om-universitetet/jobba-hos-oss/hjalp-for-sokande Application Submit your application via the University of Gothenburg's recruitment portal by clicking the "Apply" button. It is your responsibility to ensure that the application is complete as per the vacancy notice, and that the University receives it by the final application deadline. The application should contain: A short statement describing the candidate's training, interests and future goals as well as motivation to apply for this position. Curriculum Vitae Proof of completed PhD Contact details of two references Applications must be received by: 2026-08-14. Information for International Applicants Choosing a career in a foreign country is a big step. Thus, to give you a general idea of what we and Gothenburg have to offer in terms of benefits and life in general for you and your family/spouse/partner please visit: https://www.gu.se/en/about-the-university/welcome-services https://www.movetogothenburg.com/ The University works actively to achieve a working environment with equal conditions, and values the qualities that diversity brings to its operations. Salaries are set individually at the University. In accordance with the National Archives of Sweden's regulations, the University must archive application documents for two years after the appointment is filled. If you request that your documents are returned, they will be returned to you once the two years have passed. Otherwise, they will be destroyed. In connection to this recruitment, we have already decided which recruitment channels we should use. We therefore decline further contact with vendors, recruitment and staffing companies.
The position A Postdoctoral Research Fellow position is available at the Department of Medical Biology, Faculty of Health Sciences, with the research group for Host-Microbe Interactions. The position is a fixed term position for a duration of 3 years. It is a prerequisite that the applicant can carry out the project over the full course of the employment period. No person may hold more than one fixed term position as a Postdoctoral Research Fellow at the same institution. As a Postdoctoral Research Fellow, you will have the opportunity to advance your scientific career and further qualify for academic positions. If you do not already have the educational competence that meets the requirements for an Associate Professor position in Norway, UiT will arrange such competence during the employment period. The workplace is at UiT in Tromsø. You must be able to start in the position within a reasonable time after receiving the offer. Unless special circumstances indicate otherwise, postdoctoral projects shall be planned with stays abroad. The duration should be at least 6 months. The project/position's field of research The postdoctoral fellow will be part of an emerging project area headed by Prof. Christian Lentz. Combining chemical biology, molecular biology, bacterial physiology and infection biology methods, our research is dedicated to unravel how bacterial pathogens functionally adapt to their host and antibiotics and to translate these insights to develop innovative approaches to prevent, treat and diagnose bacterial infections. In particular, we are interested in understanding: i) how single cells shape the collective function of bacterial pathogen cell populations during colonization and infection, ii) how previously undercharacterized hydrolytic enzymes and dynamic changes in chemical modifications of the biomolecular landscape of bacterial cells contribute to bacterial physiology, pathogenesis and drug susceptibility, iii) understanding and modelling pathogenesis and treatment failure of difficult-to-treat clinical infections. The main model organisms used in our team are Staphylococcus aureus and Klebsiella pneumoniae. We seek a highly motivated, research-minded candidate, with a strong academic track-record and complementary research interests and expertise. The project will be tailored to the successful candidate, and the postdoctoral fellow is encouraged to develop their own research ideas and strategies within the framework of the project. The postdoctoral fellow will manage the project, design and execute experiments, and supervise students. • The postdoctoral fellow will have access to core facilities at the Faculty of Health Sciences, providing state-of-the-art technology and hands-on expertise in bioimaging, FACS, proteomics/metabolomics, genomics and animal experimentation. • The postdoctoral fellow will work in a team with local, national and international collaboration partners. • The postdoctoral fellow may contribute to the Department's teaching activities (up to 10% of the time). Teaching duties will be allocated based on the applicant's qualifications and the needs of the Department, and may include exam work, teaching seminars, and supervising or assisting in lab courses. You must submit a vision statement for how you will strengthen research activities in the research group. Contact For further information about the position, please contact Professor Christian Lentz: • Phone: (+47) 77644905 • Email: christian.s.lentz@uit.no or Professor Mona Johannessen: • Phone +47 776 46225 • Email: mona.johannessen@uit.no Qualifications Required qualifications: • Completion of a relevant PhD degree in molecular microbiology/bacterial infection biology/chemical biology or related field of study is required before starting the position. Applicants who in the final stages of their PhD are welcome to apply. • Strong academic track record and publication list • A high motivation for research and complementarity of the candidate´s research interest and expertise with ongoing research activities in the research group as is to be outlined in the candidate´s vision statement. • Strong documented skills in at least one of the following areas is required • Bacterial Pathogenesis • Cellular Microbiology • Bacterial physiology and stress responses • Molecular microbiology (related to pathogenic bacteria) • Interactions of bacterial pathogens and the human microbiome • Chemical biology applied to bacteria • Fluency in English is required. Nordic applicants can document their capabilities by attaching their high school diploma. Desired qualifications • Experience with one or several of the following techniques • Single-cell techniques and cellular phenotypic heterogeneity • Production of recombinant proteins • Flow cytometry and cell-sorting • Advanced microscopy and imaging methodologies • Genetic manipulation of bacterial pathogens and/or mammalian cells • Proteomics or Lipidomics • Animal infection models • Working knowledge of Norwegian or a Scandinavian language is desired. Nordic applicants can document their capabilities by attaching their high school diploma. In the assessment the main emphasis will be attached to the submitted works and the submitted vision statement. Emphasis shall also be attached to experience from popularization/dissemination and academic policy and administrative activity. As teaching duties or equivalent work is attached to the position, emphasis will also be attached to teaching experience and qualifications. During the assessment emphasis will be put on the candidate’s motivation, potential for research, and personal suitability for the position. We are looking for candidates who: • Have good collaboration skills and who can work both independently and in a team • Have good communication and interaction with colleagues and students • Want to contribute to a good working environment At UiT we put emphasis on the quality, relevance and significance of the research work and not on where the work is published, in accordance with the principles of The San Francisco Declaration on Research Assessment (DORA). Inclusion and diversity UiT The Arctic University i Norway is working actively to promote equality, gender balance and diversity among employees and students, and to create an inclusive and safe working environment. We believe that inclusion and diversity is a strength, and we want employees with different competencies, professional experience, life experience and perspectives. If you have a disability, a gap in your CV or immigrant background, we encourage you to tick the box for this in your application. If there are qualified applicants, we invite least one in each group for an interview. If you get the job, we will adapt the working conditions if you need it. Apart from selecting the right candidates, we will only use the information for anonymous statistics. We offer • Involvement in an interesting research project • Good career opportunities • A good academic environment with dedicated colleagues • Flexible working hours and a state collective pay agreement • Pension scheme through the state pension fund Norwegian health policy aims to ensure that everyone, irrespective of their personal finances and where they live, has access to good health and care services of equal standard. As an employee you will become member of the National Insurance Scheme which also include health care services. More practical information for working and living in Norway can be found here: https://uit.no/staffmobility Application Please note that the application will only be assessed based on the information submitted by the application deadline via Jobbnorge. It is therefore important that you include all necessary documents demonstrating your qualifications for the position. Your application must include: • Application letter • Vision statement for research activities (max 1-2 pages) • CV • Diplomas and transcripts (all degrees) • Documentation of English proficiency (If available) • Contact information to 2-3 references • Documentation of educational competence, if available • Description of your academic production, stating which works you consider most important • Academic works, up to ten. The doctoral thesis is regarded as one work. In order to achieve a targeted use of the postdoctoral position, and to strengthen the employee’s career development, a development plan must be available no later than three months after the appointment contract is signed. The development plan must be approved by the immediate leader with personnel responsibility. If you're in the final stages of your PhD, you may still apply for the position, provided that you submit parts of your dissertation along with your application. This enables the evaluation committee to assess the quality and likelihood of completion by the desired employment date. You must include a statement from your supervisor or institution stating the expected completion date for your PhD degree. Documentation of your completed PhD degree must be submitted before commencement. All documentation to be considered must be in a Scandinavian language or English. If English proficiency is not documented in the application, it must be documented before starting in the position. Assessment The applicants will be assessed by an expert committee. The committee's mandate is to undertake an assessment of the applicants' qualifications based on the written material presented by the applicants, and the detailed description draw up for the position. A copy of the assessment report will be sent to all applicants. The applicants who are assessed as best qualified will be called to an interview. The interview should among other things, aim to clarify the applicant’s motivation and personal suitability for the position. A trial lecture may also be held. General information The appointment is made in accordance with State regulations and guidelines at UiT. At our website, you will find more information for applicants. The remuneration for Postdoctoral research fellow is in accordance with the State salary scale code 1352 with a gross annual salary ranging from NOK 620.000 to 670.000 (in a 100% position). (In special cases, a higher salary may be considered.) A compulsory contribution of 2 % to the Norwegian Public Service Pension Fund will be deducted. You will become a member of the Norwegian Public Service Pension Fund, which gives you many benefits in addition to a lifelong pension. Read more about your employee benefits at: spk.no. The successful candidate must be willing to get involved in the ongoing development of their department and the university as a whole. According to the Norwegian Freedom and Information Act (Offentleglova) information about the applicant may be included in the public applicant list, also in cases where the applicant has requested non-disclosure.
About Xaira Therapeutics Xaira is an innovative biotech startup focused on leveraging AI to transform drug discovery and development. The company is leading the development of generative AI models to design protein and antibody therapeutics, enabling the creation of medicines against historically hard-to-drug molecular targets. It is also developing foundation models for biology and disease to enable better target elucidation and patient stratification. Collectively, these technologies aim to continually enable the identification of novel therapies and to improve success in drug development. Xaira is headquartered in the San Francisco Bay Area, Seattle, and London. About the Role We are seeking an exceptional and highly motivated Senior Scientist to architect and lead our efforts in in vivo CRISPR screening. In this pivotal role, you will be instrumental in advancing our mission to pioneer biological discoveries through high-throughput functional genomics. You will lead strategic initiatives that push the technical boundaries of genetic screening at the intersection of mouse models, data science, AI/ML, and translational biology. This position is ideal for a seasoned discovery scientist who excels at translating data-driven insights into therapeutic research while balancing strategic leadership with advanced individual technical contributions. Key Responsibilities * Develop, implement and scale high-throughput CRISPR-based screening protocols in mouse models to uncover genotype-phenotype relationships at scale. * Drive continuous innovation in experimental workflows and screening methodologies. * Partner with computational biology, AI/ML, and drug discovery teams to analyze, interpret, visualize, and communicate findings from large-scale functional genomics datasets. * Identify and resolve challenges in data generation, including assay reproducibility, sample throughput, and quality control. * Independently manage multiple projects, ensuring timely delivery of high-quality data and adherence to team goals. * Maintain accurate records of experiments, protocols, and findings, contributing to internal and external scientific presentations. * Mentor junior staff and research associates, fostering their scientific and professional growth through active technical guidance and career development. * Lead strategic project planning and long-term program development initiatives to ensure alignment with broader therapeutic discovery goals. * Independently drive and oversee complex cross-functional collaborations with internal and external partners to accelerate program milestones. Requirements * Ph.D. in Molecular Biology, Genetics, Pharmacology, or a related field, with 4+ years of postdoctoral or industry experience. * Strong experience with in vivo genetic manipulation (e.g., lentiviral or AAV delivery in mice), mouse handling, colony management, and in vivo experimentation, with an understanding of animal welfare and regulatory standards. * Familiarity with perturb-seq and single-cell genomics. * Ability to troubleshoot technical issues, adapt to new protocols, and optimize methodologies for in vivo applications. * Excellent written and verbal communication skills, with a track record of presenting complex scientific results to multidisciplinary teams. * Demonstrated success in working collaboratively in a fast-paced, team-oriented environment. Preferred Qualifications * Familiarity with spatial omics and interest in exploring new readout methods. * Experience in data analysis using Python or R. * Experience in in vivo CRISPR screening. Compensation We offer a competitive compensation and benefits package, seeking to provide an open, flexible, and friendly work environment to empower employees and provide them with a platform to develop their long-term careers. A Summary of Benefits is available for all applicants. We offer a competitive package that includes base salary, bonus, and equity. The base pay range for this position is expected to be $136,000 - $170,000 annually; however, the base pay offered may vary depending on the market, job-related knowledge, skills and capabilities, and experience. Xaira Therapeutics an equal-opportunity employer. We believe that our strength is in our differences. Our goal to build a diverse and inclusive team began on day one, and it will never end. TO ALL RECRUITMENT AGENCIES: Xaira Therapeutics does not accept agency resumes. Please do not forward resumes to our jobs alias or employees. Xaira Therapeutics is not responsible for any fees related to unsolicited resumes.