Data Scientist, Antibody Design (12-month FTC)

Relation Therapeutics

ABOUT RELATION Relation is a sector defining TechBio company developing transformational medicines, with technology at our core. Our ambition is to understand human biology in unprecedented ways, discovering therapies to treat some of life’s most devastating diseases. We leverage single-cell multi-omics from patient tissue, functional assays, and machine learning to drive disease understanding, from cause to cure. We are scaling rapidly and building a team of exceptional individuals to push the boundaries of drug discovery. You will work in highly interdisciplinary teams where biology, computation, and engineering come together to solve complex problems that have not been solved before. Our state-of-the-art wet and dry labs in the heart of London are designed to accelerate this integration and translate insight into impact. We are committed to building diverse and inclusive teams. Relation is an equal opportunities employer and does not discriminate on the basis of gender, sexual orientation, marital or civil partnership status, gender reassignment, race, colour, nationality, ethnic or national origin, religion or belief, disability, or age. By joining Relation, you will help define how medicines are discovered and deliver meaningful impact for patients.   THE OPPORTUNITY Relation is offering an outstanding opportunity for an Senior Scientist, Biologics Drug Discovery to bring deep biologics drug discovery knowledge to our growing pipeline. You will contribute to target assessment, modality selection and biologics discovery strategies through deep technical expertise and hands-on scientific execution from early concept through to IND-enabling studies. As Relation grows its scientific and machine learning capabilities, you will act as a highly experienced scientist, bringing deep expertise in antibody discovery and engineering while contributing directly to programme execution and scientific decision-making, working alongside our computational, ML, and translational teams to translate biological insight into well-designed molecules with a credible path to the clinic. We are particularly interested in scientists who have personally designed, engineered and optimised antibody molecules, including experience with affinity maturation, CDR engineering, developability assessment and data-driven molecule optimisation. You will additionally be a key technical voice in pipeline decisions and a trusted partner to colleagues across Drug Discovery and beyond.   DAY TO DAY, YOU WILL * Demonstrated hands-on experience designing, engineering and optimising antibody molecules, with a strong understanding of the experimental approaches used to assess potency, selectivity, developability and mechanism of action. * Ability to independently interpret complex datasets and use those data to drive molecule design and optimisation decisions. * Maintain a hands-on role in biologics discovery activities while partnering closely with internal and external teams. * Drive biologics programs end-to-end — from target validation and hit identification through lead characterization, optimization, and developability triage — against agreed Target Product Profiles (TPPs). * Make informed modality decisions across the biologics landscape (antibodies, bispecifics, ADCs, fusion proteins, fragments) and ensure the right molecule is selected for the right target and indication. * Design and oversee fit-for-purpose discovery packages, combining cell-based functional assays, biophysical characterization (SPR/Biacore, BLI/Octet), and developability assessment to drive sound candidate selection. * Operate effectively in a matrixed pharma/biotech environment, partnering with Computational Biology, Machine Learning, CMC, DMPK, Toxicology, and Translational colleagues to de-risk candidates and progress them toward IND-enabling studies. * Partner with external collaborators and CROs, contributing to study design, data review and scientific interpretation. * Share expertise with colleagues and contribute to a collaborative scientific environment. * Partner with our ML and computational biology teams to bring biologics drug discovery insight into how predictive and generative approaches are applied to target selection, molecule design, and lead optimization. * Personally contribute to the design, engineering and optimisation of antibody molecules, using experimental data to guide scientific decisions and progression strategies. * Contribute to Relation’s scientific culture by mentoring junior scientists in biologics drug discovery, supporting publications and conference visibility, and helping to shape the broader scientific identity of the biologics group.   PROFESSIONALLY, YOU WILL HAVE * A PhD. in Molecular Biology, Immunology, Pharmacology, Cell Biology, Protein Engineering, or a related life-science discipline. * Hands-on drug discovery experience gained in a pharma or biotech setting, with a clear track record of contributing to biologics programs progressing through key discovery milestones (target validation, hit-to-lead, lead optimization, candidate selection). * Proven experience working in a matrixed pharma/biotech environment, partnering effectively across functions (e.g. CMC, DMPK, Toxicology, Computational/ML, Translational) and balancing multiple stakeholders. * Deep working knowledge of biologics drug discovery: how biology is translated into a molecule, how modalities are chosen, how discovery cascades are designed, and what data are needed at each stage to make sound progression decisions. * Familiarity with the biologics modality landscape (antibodies, bispecifics, ADCs, fusion proteins, fragments) and an informed view of when each modality is the right tool for the biology. * Hands-on experience with the data types that drive biologics drug discovery decisions, including cell-based functional and screening assays and biophysical characterization (SPR/Biacore, BLI/Octet). * Working experience of CRO management across biologics drug discovery activities (e.g. molecule production, in vitro pharmacology, in vivo studies). * A good understanding of biologics drug discovery end-to-end, including TPP-driven decision-making, developability considerations, and awareness of what is required to support IND-enabling activities. * Curiosity about how ML and computational approaches can complement traditional biologics discovery workflows, and an interest in shaping how those tools are deployed. Bonus experience: * Familiarity with bone biology and bone-microenvironment models (osteoblast, osteoclast, osteocyte; mineral-binding or resorption assays). * Peer-reviewed publications in the biologics drug discovery space, prior experience mentoring junior scientists, and exposure to a TechBio or computationally-driven discovery environment are also welcome.   PERSONALLY, YOU: * Are comfortable working in a matrixed environment, balancing multiple stakeholders and contributing effectively across teams. * Take ownership of your work, proactively seek opportunities to contribute, and enable others to do their best work. * Communicate openly and directly, give and receive feedback constructively, and handle challenging conversations with respect. * Actively seek out diverse perspectives, build strong working relationships, and contribute to shared goals across teams. * Embrace challenges with openness and resilience, set high standards for yourself, and strive to deliver meaningful outcomes.   WORKING STYLE & CULTURE AT RELATION At Relation, we operate in a matrixed, interdisciplinary environment, where impact is driven through collaboration across scientific, technical, and operational domains. We collaborate, and you will partner with colleagues across multiple teams and projects, contributing your expertise while aligning to shared company priorities. We work together and win together! The patient is waiting!   RECRUITMENT AGENCIES Please note that Relation does not accept unsolicited resumes from agencies. Resumes should not be forwarded to our job aliases or employees. Relation will not be liable for any fees associated with unsolicited CVs. Relation is a committed equal opportunities employer.

Engitix

YOUR MISSION Engitix Therapeutics is a pioneering biotechnology company unlocking extracellular matrix (ECM) biology to develop transformative therapeutics for fibrosis and oncology. By combining proprietary human ECM-based platforms with advanced cellular models, we are uncovering novel biology at the immune-stromal interface and translating these insights into innovative drug discovery programmes.  We are seeking a talented Scientist with expertise in macrophage and myeloid biology to join our Discovery Biology team.  The Role  This is an exciting opportunity to play a key role in advancing our understanding of macrophage and myeloid cell biology in fibrosis and cancer.  You will combine expertise in primary human immune cells with cutting-edge cellular and functional assays to investigate macrophage heterogeneity, activation states, and immune-stromal interactions within disease-relevant microenvironments. Working closely with colleagues across Discovery Biology, BioPlatforms and Data Science, you will generate insights that support target discovery, mechanism-of-action studies, and therapeutic screening efforts.  The successful candidate will be a highly motivated experimental scientist who enjoys working at the bench and is excited by the opportunity to establish new biological capabilities, develop innovative cellular models and assays, and contribute directly to discovery programmes. This role offers significant scientific ownership, exposure to early drug discovery, and the opportunity to apply state-of-the-art immunology approaches to uncover novel biology and therapeutic opportunities.  Key Responsibilities  * Establish scalable workflows for processing human blood and leukopak samples, including PBMC isolation and generation of primary human macrophages. * Develop, optimise, and execute functional assays using primary and engineered immune cells, with a particular focus on macrophages and other myeloid cell populations. * Perform multi-colour and high-parameter flow cytometry for immune cell phenotyping and functional characterisation. * Design and execute macrophage activation, phagocytosis, cytokine secretion, and co-culture assays to investigate target biology and therapeutic activity. * Develop and apply approaches to understand macrophage heterogeneity and function within disease-relevant microenvironments. * Support the development of immune-stromal and ECM-based cellular models for target discovery and therapeutic screening. * Analyse, interpret, and communicate experimental findings to multidisciplinary project teams. * Contribute to the development of new macrophage and myeloid biology capabilities through implementation of innovative technologies, cellular models, and experimental approaches. * Maintain accurate laboratory records and support safe and efficient laboratory operations. YOUR PROFILE Essential  * Strong background in macrophage and myeloid cell biology. * Significant hands-on experience handling human blood samples, leukopak processing, PBMC isolation, and immune cell culture. * Experience deriving, characterising, and functionally evaluating primary human macrophages. * Strong experience with multi-colour and/or high-parameter flow cytometry, including immune phenotyping and data analysis. * Experience developing and executing immune cell-based functional assays. * Strong experimental, analytical, and problem-solving skills. * Excellent communication skills and ability to work effectively within multidisciplinary teams. Desirable  * Experience in immuno-oncology, fibrosis, inflammation, or tissue remodelling research. * Experience with antibody-based therapeutics or immune-modulating agents. * Experience with stromal biology, extracellular matrix biology, or immune-stromal co-culture systems. * Experience with molecular biology techniques such as qPCR, RNA analysis, CRISPR-based perturbation, or gene knockdown approaches. * Previous experience in a biotechnology or pharmaceutical research environment. Qualifications  * PhD in Immunology, Cell Biology, Biomedical Sciences, Cancer Biology, or a related discipline. * Typically 2–4 years of relevant postdoctoral and/or industry experience. * Demonstrated ability to independently design, execute, troubleshoot, and interpret experiments. * Passion for hands-on laboratory research and scientific discovery. WHY US? * Work at the forefront of immune-stromal biology in fibrosis and oncology. * Contribute directly to target discovery and early drug development programmes. * Apply cutting-edge technologies to answer important biological questions with therapeutic relevance. * Collaborate within a highly multidisciplinary internal and external teams and innovative research environment. * Gain broad exposure to drug discovery while maintaining strong scientific and technical ownership. * Help deliver transformative therapies for patients with significant unmet medical need.

Isomorphic Labs

Isomorphic Labs is applying frontier AI to help unlock deeper scientific insights, faster breakthroughs, and life-changing medicines with an ambition to solve all disease. The future is coming. A future enabled and enriched by the incredible power of machine learning. A future in which diseases are curtailed or cured starting with better and faster drug discovery.  Come and be part of an interdisciplinary team driving groundbreaking innovation and play a meaningful role in contributing towards us achieving our ambitious goals, while being a part of an inspiring and collaborative culture. The world we want tomorrow is the one we’re building today. It starts with the culture at this company. It starts with you.    ABOUT ISO Isomorphic Labs (IsoLabs) was launched in 2021 to advance human health by building on and beyond the Nobel-winning AlphaFold system. Since then, our interdisciplinary team of drug discovery experts and machine learning specialists has built powerful new predictive and generative AI models that accelerate scientific discovery at digital speed. Our name comes from the belief that there is an underlying symmetry between biology and information science. By harnessing AI’s powerful capabilities, we can use it to model complex biological phenomena to help design novel molecules, anticipate how drugs will perform and develop innovative medicines to treat and cure some of the world’s most devastating diseases. We have built a world-leading drug design engine comprising AI models that are capable of working across multiple therapeutic areas and drug modalities. We are continually innovating on model architecture and developing cutting-edge capabilities to advance rational drug design. Every day, and with each new breakthrough, we’re getting closer to the promise of digital biology, and achieving our ambitious mission to one day solve all disease with the help of AI.   YOUR MISSION We are seeking a highly innovative and experienced Bioanalytical Lead to bridge the gap between our predictive AI design platform and wet-lab preclinical execution. In this role, you will define the overarching bioanalytical strategy across our expanding portfolio, covering small molecules, advanced biologic formats, and Antibody-Drug Conjugates (ADCs) in both non-GLP and GLP environments. You will collaborate closely with the drug design teams, design robust bioanalytical assays, manage global Contract Research Organizations (CROs), and lead the logistical execution required to rapidly advance our candidates toward IND submission. As the Bioanalytical Lead, you will serve as the technical expert for our diverse portfolio of computationally designed therapeutic candidates. As part of the preclinical development function, this is a high-impact leadership role responsible for building the bridge between Isomorphic’s AI-driven discovery engine and the effective execution of our robust preclinical strategies, alongside safety and DMPK. The successful candidate will be forward thinking, thrive in fast-paced, agile environment and ready to embrace Iso’s AI-first mindset and challenge the status quo. With a broad range of internal and external stakeholders, candidates will be expected to have exceptional communication and influencing skills.   BIOANALYTICAL STRATEGY & AI INTEGRATION * Define and execute comprehensive bioanalytical strategies for small molecules, large molecules, and complex modalities (ADCs) from discovery through preclinical development covering both non-GLP and GLP environments. * Oversee the design, validation, and transfer of robust PK, PD, and immunogenicity (ADA) assays at external labs. * Collaborate with AI/machine learning scientists to integrate bioanalytical data back into predictive models, helping to continuously improve our platform's accuracy. * Lead biomarker assay strategies, utilizing both traditional approaches and AI-identified novel biomarkers to support preclinical proof-of-concept.   GLOBAL CRO MANAGEMENT & LOGISTICS * Select, qualify, and manage a high-performing network of global CRO partners, ensuring rigorous data quality, strict timelines, and budget alignment. * Master complex global logistics, including international sample shipments, cold-chain management, import/export compliance, and stability tracking across borders to ensure data integrity. * Serve as the primary technical point of contact for CROs, troubleshooting complex assay anomalies rapidly.   CROSS-FUNCTIONAL LEADERSHIP AND REGULATORY AUTHORING * Work seamlessly at the intersection of Drug Discovery, Translational Medicine, and Computational Biology to drive candidates into the clinic. * Author and review high-quality regulatory documents, specifically bioanalytical sections of Investigational New Drug (IND) applications and Investigator Brochures (IBs). * Represent the bioanalytical function in cross-functional project teams and during interactions with regulatory agencies (FDA, EMA, etc.).   REQUIRED EXPERTISE AND EXPERIENCE * Ph.D. in Biochemistry, Analytical Chemistry, Pharmacology, or a related scientific discipline with 5+ years of biotech/pharmaceutical industry experience; OR a B.S./M.S. with 8+ years of equivalent experience. * Proven track record of leading bioanalytical strategies across multiple modalities (must include small molecules, biologics, and ADCs). * Deep understanding of GLP and non-GLP preclinical study regulations, FDA/EMA bioanalytical method validation guidelines, and ICH guidelines. * Technical & Logistical Expertise * Extensive experience with diverse analytical platforms (e.g., LC-MS/MS, LBA, flow cytometry). * Demonstrated success in biomarker assay development and validation. * Expert knowledge of global sample shipping logistics, biosafety regulations, and maintaining chain-of-custody for precious preclinical samples. * Experience writing bioanalytical sections for successful IND submissions.   NICE TO HAVE * Experience of generating reagent in collaboration with drug design teams * Experience of developing or using AI tools (LLM) to accelerate processes including reporting CULTURE AND VALUES We are guided by our shared values. It's not about finding people who think and act in the same way. These values help to guide our work and will continue to strengthen it.  Thoughtful Thoughtful at Iso is about curiosity, creativity and care. It is about good people doing good, rigorous and future-making science every single day. Brave Brave at Iso is about fearlessness, but it’s also about initiative and integrity. The scale of the challenge demands nothing less. Determined Determined at Iso is the way we pursue our goal. It’s a confidence in our hypothesis, as well as the urgency and agility needed to deliver on it. Because disease won’t wait, so neither should we. Together Together at Iso is about connection, collaboration across fields and catalytic relationships. It’s knowing that transformation is a group project, and remembering that what we’re doing will have a real impact on real people everywhere. CREATING AN EXTRAORDINARY COMPANY We believe that to be successful we need a team with a range of skills and talents. We're building an environment where collaboration is fundamental, learning is shared and every employee feels supported and able to thrive. We value unique experiences, knowledge, backgrounds, and perspectives, and harness these qualities to create extraordinary impact. We are committed to equal employment opportunities regardless of sex, race, religion or belief, ethnic or national origin, disability, age, citizenship, marital, domestic or civil partnership status, sexual orientation, gender identity, pregnancy or related condition (including breastfeeding) or any other basis protected by applicable law. If you have a disability or additional need that requires accommodation, please do not hesitate to let us know. HYBRID WORKING It’s hugely important for us to share knowledge and build strong relationships with each other, and we find it easier to do this if we spend time together in person. This is why we follow a hybrid model, and would require you to be able to come into the office 3 days a week (currently Tuesday, Wednesday, and one other day depending on which team you’re in). If you have additional needs that would prevent you from following this hybrid approach, we’d be happy to talk through these if you’re selected for an initial screening call. Please note that when you submit an application, your data will be processed in line with our privacy policy. >> Click to view other open roles at Isomorphic Labs