Scientist - Cell Biology

Relation Therapeutics

ABOUT RELATION Relation is a sector defining TechBio company developing transformational medicines, with technology at our core. Our ambition is to understand human biology in unprecedented ways, discovering therapies to treat some of life’s most devastating diseases. We leverage single-cell multi-omics from patient tissue, functional assays, and machine learning to drive disease understanding, from cause to cure. We are scaling rapidly and building a team of exceptional individuals to push the boundaries of drug discovery. You will work in highly interdisciplinary teams where biology, computation, and engineering come together to solve complex problems that have not been solved before. Our state-of-the-art wet and dry labs in the heart of London are designed to accelerate this integration and translate insight into impact. We are committed to building diverse and inclusive teams. Relation is an equal opportunities employer and does not discriminate on the basis of gender, sexual orientation, marital or civil partnership status, gender reassignment, race, colour, nationality, ethnic or national origin, religion or belief, disability, or age. By joining Relation, you will help define how medicines are discovered and deliver meaningful impact for patients. THE OPPORTUNITY We are seeking a Senior Data Scientist, Computational Biology to join Relation, working at the intersection of single-cell biology, spatial omics, and machine learning. In this role, you will apply advanced computational and statistical approaches to analyse high-dimensional biological datasets, generating insights that directly inform disease understanding and drug discovery. You will sit within the Single Cell & Spatial Omics function, working closely with ML researchers, experimental scientists, and software engineers to translate complex biological data into actionable knowledge. This is a highly collaborative, scientifically driven role, suited to someone who enjoys working deeply with data, challenging models with biological insight, and contributing meaningfully to interdisciplinary research programmes. DAY TO DAY, YOU WILL * Analyse and interpret single-cell, spatial, and other multi-omics datasets to uncover biological mechanisms relevant to disease and therapeutic intervention. * Develop and apply statistical and computational methods for transcriptomics and related omics data. * Use domain expertise to design rigorous evaluation tasks that test, challenge, and refine ML models. * Collaborate closely with ML scientists to inform model assumptions, features, and interpretation. * Work with experimental teams to help design experiments and validate computational hypotheses. * Clearly communicate insights, results, and methodologies to internal stakeholders and contribute to scientific publications. PROFESSIONALLY, YOU WILL HAVE * A PhD in computational biology, bioinformatics, statistics, physics, mathematics, or a related quantitative field. * Strong experience working with high-dimensional biological data, including transcriptomics and other omics modalities. * Proficiency in Python, with experience in scientific computing and data analysis. * A solid understanding of statistical modelling and quantitative methods applied to biological data. * Experience with Bayesian models. Bonus experience * Hands-on experience with single-cell and/or spatial omics data, including patient-derived samples. * Familiarity with machine learning approaches used in biological or biomedical research. * Experience working in interdisciplinary teams spanning biology, data science, and ML. * Exposure to scalable computing environments. PERSONALLY, YOU * Are comfortable working in a matrixed environment, balancing multiple stakeholders and contributing effectively across teams. * Take ownership of your work, proactively seek opportunities to contribute, and enable others to do their best work. * Communicate openly and directly, give and receive feedback constructively, and handle challenging conversations with respect. * Actively seek out diverse perspectives, build strong working relationships, and contribute to shared goals across teams. * Embrace challenges with openness and resilience, set high standards for yourself, and strive to deliver meaningful outcomes. WORKING STYLE & CULTURE AT RELATION At Relation, we operate in a matrixed, interdisciplinary environment, where impact is driven through collaboration across scientific, technical, and operational domains. We collaborate, and you will partner with colleagues across multiple teams and projects, contributing your expertise while aligning to shared company priorities. We work together and win together! The patient is waiting! RECRUITMENT AGENCIES Please note that Relation does not accept unsolicited resumes from agencies. Resumes should not be forwarded to our job aliases or employees. Relation will not be liable for any fees associated with unsolicited CVs. Relation is a committed equal opportunities employer.

Engitix

YOUR MISSION Engitix Therapeutics is a pioneering biotechnology company unlocking extracellular matrix (ECM) biology to develop transformative therapeutics for fibrosis and oncology. By combining proprietary human ECM-based platforms with advanced cellular models, we are uncovering novel biology at the immune-stromal interface and translating these insights into innovative drug discovery programmes.  We are seeking a talented Scientist with expertise in macrophage and myeloid biology to join our Discovery Biology team.  The Role  This is an exciting opportunity to play a key role in advancing our understanding of macrophage and myeloid cell biology in fibrosis and cancer.  You will combine expertise in primary human immune cells with cutting-edge cellular and functional assays to investigate macrophage heterogeneity, activation states, and immune-stromal interactions within disease-relevant microenvironments. Working closely with colleagues across Discovery Biology, BioPlatforms and Data Science, you will generate insights that support target discovery, mechanism-of-action studies, and therapeutic screening efforts.  The successful candidate will be a highly motivated experimental scientist who enjoys working at the bench and is excited by the opportunity to establish new biological capabilities, develop innovative cellular models and assays, and contribute directly to discovery programmes. This role offers significant scientific ownership, exposure to early drug discovery, and the opportunity to apply state-of-the-art immunology approaches to uncover novel biology and therapeutic opportunities.  Key Responsibilities  * Establish scalable workflows for processing human blood and leukopak samples, including PBMC isolation and generation of primary human macrophages. * Develop, optimise, and execute functional assays using primary and engineered immune cells, with a particular focus on macrophages and other myeloid cell populations. * Perform multi-colour and high-parameter flow cytometry for immune cell phenotyping and functional characterisation. * Design and execute macrophage activation, phagocytosis, cytokine secretion, and co-culture assays to investigate target biology and therapeutic activity. * Develop and apply approaches to understand macrophage heterogeneity and function within disease-relevant microenvironments. * Support the development of immune-stromal and ECM-based cellular models for target discovery and therapeutic screening. * Analyse, interpret, and communicate experimental findings to multidisciplinary project teams. * Contribute to the development of new macrophage and myeloid biology capabilities through implementation of innovative technologies, cellular models, and experimental approaches. * Maintain accurate laboratory records and support safe and efficient laboratory operations. YOUR PROFILE Essential  * Strong background in macrophage and myeloid cell biology. * Significant hands-on experience handling human blood samples, leukopak processing, PBMC isolation, and immune cell culture. * Experience deriving, characterising, and functionally evaluating primary human macrophages. * Strong experience with multi-colour and/or high-parameter flow cytometry, including immune phenotyping and data analysis. * Experience developing and executing immune cell-based functional assays. * Strong experimental, analytical, and problem-solving skills. * Excellent communication skills and ability to work effectively within multidisciplinary teams. Desirable  * Experience in immuno-oncology, fibrosis, inflammation, or tissue remodelling research. * Experience with antibody-based therapeutics or immune-modulating agents. * Experience with stromal biology, extracellular matrix biology, or immune-stromal co-culture systems. * Experience with molecular biology techniques such as qPCR, RNA analysis, CRISPR-based perturbation, or gene knockdown approaches. * Previous experience in a biotechnology or pharmaceutical research environment. Qualifications  * PhD in Immunology, Cell Biology, Biomedical Sciences, Cancer Biology, or a related discipline. * Typically 2–4 years of relevant postdoctoral and/or industry experience. * Demonstrated ability to independently design, execute, troubleshoot, and interpret experiments. * Passion for hands-on laboratory research and scientific discovery. WHY US? * Work at the forefront of immune-stromal biology in fibrosis and oncology. * Contribute directly to target discovery and early drug development programmes. * Apply cutting-edge technologies to answer important biological questions with therapeutic relevance. * Collaborate within a highly multidisciplinary internal and external teams and innovative research environment. * Gain broad exposure to drug discovery while maintaining strong scientific and technical ownership. * Help deliver transformative therapies for patients with significant unmet medical need.

Relation Therapeutics

ABOUT RELATION Relation is a sector defining TechBio company developing transformational medicines, with technology at our core. Our ambition is to understand human biology in unprecedented ways, discovering therapies to treat some of life’s most devastating diseases. We leverage single-cell multi-omics from patient tissue, functional assays, and machine learning to drive disease understanding, from cause to cure. We are scaling rapidly and building a team of exceptional individuals to push the boundaries of drug discovery. You will work in highly interdisciplinary teams where biology, computation, and engineering come together to solve complex problems that have not been solved before. Our state-of-the-art wet and dry labs in the heart of London are designed to accelerate this integration and translate insight into impact. We are committed to building diverse and inclusive teams. Relation is an equal opportunities employer and does not discriminate on the basis of gender, sexual orientation, marital or civil partnership status, gender reassignment, race, colour, nationality, ethnic or national origin, religion or belief, disability, or age. By joining Relation, you will help define how medicines are discovered and deliver meaningful impact for patients. THE OPPORTUNITY Relation is offering an outstanding opportunity for an experienced Senior Research Assistant in Cell Biology to help drive our growing drug discovery portfolio. We are looking for a drug discovery scientist with hands-on experience in experimental design and assay development, data collection, analysis, and interpretation. In this role, you will be at the forefront of scientific discovery and make a meaningful impact in the field of biology, working at the intersection of science and technology within a rapidly growing TechBio company. You will partner closely with colleagues across Discovery and have the opportunity to develop your skills, work independently, and advance your knowledge base in assay development and optimisation. DAY TO DAY, YOU WILL * Design and execute cellular and biochemical assays to support drug discovery, including compound screening and profiling using molecular biology, cell culture, microscopy, and biochemical techniques. * Maintain primary and immortalised mammalian cell lines, taking responsibility for sample tracking and quality control (QC). * Monitor laboratory operations, including managing reagent stock levels, equipment maintenance, and adherence to good laboratory practice. * Carry out data analysis and relevant quality assurance protocols. * Communicate the outcomes of your work to team members and external parties through written and verbal reports. * Proactively identify potential project issues and communicate proposed solutions to the team. * Contribute to the development and implementation of new technologies, workflows, and operational infrastructure. * Stay up to date with relevant scientific literature and incorporate new findings into research project planning and experimental design. * Collaborate closely with cross-functional colleagues across Biology, Machine Learning, Translational Sciences, Toxicology, DMPK, and related disciplines to help solve complex scientific challenges and accelerate programme delivery. PROFESSIONALLY, YOU WILL HAVE * Master’s degree in a Biological Science with 4+ years of relevant experience within a drug discovery function. * Prior experience working within biotech, pharmaceutical, or CRO environments. * Strong practical experience in cell culture techniques, including cell line generation. * Ability to develop cellular, molecular biology, and immunological assays to characterise cell phenotypes, e.g. flow cytometry, RT-qPCR, ELISA, etc. * Hands-on experience with high-content imaging instrumentation and software. * Experience with ‘walk-up’ automated laboratory systems (e.g. liquid handling). * Competence in data handling, curve fitting, and statistical analysis. * Experience with industry-standard record keeping. * Excellent interpersonal and communication skills, with the ability to thrive in a collaborative, cross-functional, matrixed environment. * Highly motivated, scientifically rigorous, and comfortable operating in a fast-paced, evolving biotech setting. Bonus experience: * ‘Walk-up’ automated laboratory systems (e.g. liquid handling). * Working with ’omics experiments and datasets. * Generating knock-out/knock-in cell lines using siRNA and CRISPR. * Working in indications relevant to Relation (e.g. osteoporosis) and with a range of modalities in addition to small molecules, such as peptides, ADCs, oligonucleotides, or targeted delivery approaches. PERSONALLY, YOU * Are comfortable working in a matrixed environment, balancing multiple stakeholders and contributing effectively across teams. * Take ownership of your work, proactively seek opportunities to contribute, and enable others to do their best work. * Communicate openly and directly, give and receive feedback constructively, and handle challenging conversations with respect. * Actively seek out diverse perspectives, build strong working relationships, and contribute to shared goals across teams. * Embrace challenges with openness and resilience, set high standards for yourself, and strive to deliver meaningful outcomes. WORKING STYLE & CULTURE AT RELATION At Relation, we operate in a matrixed, interdisciplinary environment, where impact is driven through collaboration across scientific, technical, and operational domains. We collaborate, and you will partner with colleagues across multiple teams and projects, contributing your expertise while aligning to shared company priorities. We work together and win together! The patient is waiting! RECRUITMENT AGENCIES Please note that Relation does not accept unsolicited resumes from agencies. Resumes should not be forwarded to our job aliases or employees. Relation will not be liable for any fees associated with unsolicited CVs. Relation is a committed equal opportunities employer.