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PhD Position

Department of Pediatric Research, Oslo University Hospital

OrtOslo
Omfattning–
Sista ansökan26 dagar kvar
Publicerad19 okt.

Om tjänsten

3-year 100% PhD position is available at the Department of Pediatric Research, OUS Rikshospitalet for a highly motivated and skilled PhD student on a project funded by South-Eastern Norway Regional Health Authority. The position is available from 23rd November 2026.

Neonatal cholestasis is a condition with impaired bile flow causing accumulation of bile acids and bilirubin, liver damage and debilitating pruritus. Reduction in bile to the intestine results in malabsorption, reduced weight gain, vitamin deficiency and changes in microbiota. Both genetic and environmental factors can result in cholestasis.

About the Department / Research Group

Professor Runar Almaas (Pediatric hepatology) at PFI, OUS is leading the project. The PhD candidate will be supervised by him and by Co-supervisor Barbora Smolkova (PhD) and senior researcher Gareth Sullivan. The group is using induced pluripotent stem cells for making liver organoids and a major part of the work will be related to this model.

Oslo University Hospital is a workplace with great diversity. We believe this is crucial for solving our tasks in the best possible way. We want this diversity to be reflected among the applicants for our positions, and we encourage all qualified candidates, regardless of background, to apply!

Duties and responsabilities

What Tasks and Responsibilities Are Associated with the Position?

To reveal mechanisms of cholestasis and pruritus and to investigate novel potential treatments we are using liver organoids derived from disease-specific induced pluripotent stem cells. iPSC-derived liver organoids are a unique model that can mimic key features of the human liver and can be used to study liver development and disease. In these project liver organoids will be used for studying protein trafficking, effect of modulating factors and potential drugs.

Qualifications

Master degree (or equivalent) in medicine, biomedicine, biotechnology, or molecular biology

Good practical skills in various extraction, quantification, and analysis of nucleic acids (DNA and RNA) and proteins including qRT-PCR, ddPCR, and Western blotting are advantages

Skills and prior experience in cell cultivation and handling is an advantage

experience in other relevant molecular biology techniques including gene editing using CRISPR/Cas9 technology, next-generation sequencing, etc is an advantage

Experience in scientific writing / presentation is an advantage

Good written and oral communication skills in English

Practical Information

We request that relevant documentation be attached to the application. Please note that all documents should be in English or a Scandinavian language.

Personal qualities

We are looking for a highly dedicated, reliable and highly motivated candidate with great working capacity

We expect scientific curiosity and understanding about the nature of scientific thinking

You have a strong interest in completing your tasks in structured way.

You are able to design, plan, perform, and analyze experiments in an innovative way

The candidate is expected to work together with engineers and other scientists in a team. Ability to work independently, but with good communication skills is preferred.

We can offer