Postdoctoral studies in microglial contributions to autism spectrum disorders (scholarship)

Do you want to contribute to top quality medical research? Join our internationally recognized research team to investigate how

microglia shape brain development and contribute to autism spectrum disorders. You will work in a collaborative environment

combining expertise in microglial biology, molecular signalling and neurodevelopment, with access to human stem cell-derived

models, and complementary animal models. At the Institute for Environmental Medicine (IMM), Karolinska Institutet, you will have

opportunities to develop your scientific independence, strengthen your experimental and analytical skills, and collaborate with

national and international partners. Division A postdoctoral scholarship is available in the lab of Bertrand Joseph at the

Institute of Environmental Medicine, Karolinska Institutet.  The Joseph lab is internationally recognized in field of microglia

for its research focusing on understanding how microglia contribute to the healthy and diseased brain. Highlights from the team

include the discovery of a role for killer caspases in driving pro-inflammatory and tumour-supportive microglial phenotypes and a

contribution to the understanding of the transcriptional/epigenetic regulation of microglial activation states and the possibility

to reprogram microglia toward distinct phenotypes. Lately, the team has been arguing for the concept of microglia diversity, i.e.,

the existence of microglial subtypes. Duties The project will be centred on the hypothesis that genetic alterations and prenatal

immune challenges associated with autism spectrum disorders (ASD) disrupt the identity and function of distinct microglial

populations, thereby affecting neuronal maturation, neural circuit development and behaviour. The successful candidate will

investigate these mechanisms using complementary human in vitro systems and in vivo mouse models, with particular attention to

developmental stage, brain region and sex-specific differences. We seek a curious, highly motivated and creative postdoctoral

researcher with a strong background in microglial biology, neurodevelopment and/or neurodevelopmental disorders. The ideal

candidate should have documented experience in molecular and cellular research. Experience with human iPSC-derived models,

microglia–neuron co-cultures, flow cytometry, advanced imaging or animal models of neurodevelopmental disorders is considered an

advantage. Expertise in bioinformatics is also a strength. The candidate should be able to work independently and in a structured

manner, while contributing effectively to a collaborative research environment. Excellent interpersonal skills and proficiency in

written and spoken English are required. Emphasis will be placed on personal suitability and the ability to work well within the

research group. Entry requirements Postdoctoral scholarships may be established for foreign researchers who pursue their merit in

Sweden. A foreign researcher is a person living in another country who comes to Sweden with the intention of only staying in

Sweden for all or part of their postdoctoral education at KI. Persons who are resident in Sweden and/or have carried out all or

part of their academic education at KI or some other educational institution in Sweden cannot be considered for scholarships. The

purpose of scholarships for postdoctoral qualification is to promote internationalization and contribute to research qualification

after a doctorate or equivalent. A scholarship for carrying out postdoctoral research can be granted for a maximum of two years

within a four-year period following the receipt of a doctoral degree or equivalent. To be eligible for a postdoctoral scholarship,

the person must have obtained a doctorate, or a foreign degree deemed to be equivalent to a doctorate. Applicants who have not

completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree

are met before the (intended) start date of the post-doctoral education. What do we offer? A creative and inspiring environment

with wide-ranging expertise and interests. Karolinska Institutet is one of the world's leading medical universities. Here, we

conduct innovative medical research and provide the largest range of biomedical education in Sweden. At KI, you get to meet

researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and

experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI

to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A

close relationship with the health care providers is important for creating groundbreaking top quality education and research.

Students and employees have free access to our modern gym facilities with trained staff on site. Location: Type of scholarship The

amount is tax free and it is set for twelve months at a time, paid out on a six months basis. In exceptional cases, shorter

periods may be acceptable. Application process An application must contain the following documents in English or Swedish: - A

complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title,

current position, academic distinctions, and committee work - A complete list of publications - A summary of current work (no more

than one page) The application is to be submitted on the Varbi recruitment system. Want to make a difference? Join us and

contribute to better health for all